{"id":"W2166603832","doi":"10.1146/annurev-ecolsys-110411-160257","title":"Mutation Load: The Fitness of Individuals in Populations Where Deleterious Alleles Are Abundant","year":2012,"lang":"en","type":"article","venue":"Annual Review of Ecology Evolution and Systematics","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":276,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto","funders":"","keywords":"Genetic load; Biology; Epistasis; Inbreeding; Population; Intraspecific competition; Mutation; Genetics; Allele; Selection (genetic algorithm); Mutation rate; Balancing selection; Competition (biology); Evolutionary biology; Mutation Accumulation; Ecology; Demography; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008675726,0.0005841536,0.0009474313,0.001856009,0.0003879529,0.001277182,0.0006975579,0.0007911315,0.00268803],"category_scores_gemma":[0.002888584,0.0001394531,0.0003146569,0.002059035,0.001008776,0.001911811,0.0008261431,0.000564556,0.0007663545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007761384,"about_ca_system_score_gemma":0.0002678023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009648959,"about_ca_topic_score_gemma":0.000847752,"domain_scores_codex":[0.9994717,0.0001160372,0.00004665667,0.0001461169,0.0001739142,0.00004547766],"domain_scores_gemma":[0.9988185,0.000430589,0.0003626703,0.0001000464,0.0001545882,0.0001336959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005148525,0.0002321476,0.2893898,0.002063594,0.001060795,0.001742468,0.001271526,0.01237473,0.1406782,0.050521,0.01143946,0.4887115],"study_design_scores_gemma":[0.00003799318,0.0007940733,0.7689399,0.0005164852,0.0004042149,0.009738673,0.000858394,0.01709915,0.02862192,0.09754888,0.07516094,0.0002793559],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8751024,0.06042856,0.0339082,0.00191033,0.0006131872,0.00007467841,0.002761595,0.0004507259,0.02475034],"genre_scores_gemma":[0.9703564,0.01330305,0.007087966,0.0003074626,0.0002630512,0.00006037842,0.001568466,0.00008380076,0.006969292],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00268803,"threshold_uncertainty_score":0.008992314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390385330929996,"score_gpt":0.2919323572909049,"score_spread":0.278028503981605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}