{"id":"W2166616682","doi":"10.1152/ajplung.00303.2011","title":"Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells","year":2012,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Epithelial sodium channel; Cystic fibrosis transmembrane conductance regulator; Apical membrane; Epithelium; HEK 293 cells; Cell biology; Proteases; Transmembrane protein; Chemistry; Respiratory epithelium; Serine protease; Protease; Biology; Internal medicine; Biochemistry; Enzyme; Gene; Medicine; Genetics; Receptor; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003263369,0.000344967,0.0004428217,0.0001496944,0.0001838891,0.0003204965,0.0002023313,0.0002594487,0.0009329039],"category_scores_gemma":[0.0001982192,0.000145925,0.0004947133,0.0002970358,0.000155983,0.0001786244,0.0001986756,0.0005335113,0.0005677763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002142206,"about_ca_system_score_gemma":0.000235458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006887364,"about_ca_topic_score_gemma":0.0008005861,"domain_scores_codex":[0.9994683,0.0001206288,0.00006056891,0.00009417615,0.0001479523,0.000108495],"domain_scores_gemma":[0.9998977,0.00002772085,0.00001455116,0.00002263632,0.00002362328,0.00001380948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001244798,0.00002991552,0.00008683121,0.00005072559,0.000003894479,0.00004057219,0.00002216796,0.00003060275,0.9984335,0.0000426316,0.00003796368,0.001096618],"study_design_scores_gemma":[0.0000173385,0.0003531637,0.002837764,0.000005659728,0.00001619506,0.0002114735,0.00002867315,0.001032723,0.9931623,0.00001797349,0.002313568,0.000003291764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760561,0.009646242,0.008490629,0.0002552424,0.0001197135,0.0001477396,0.00110941,0.00008934117,0.004085542],"genre_scores_gemma":[0.9759955,0.005354009,0.009299274,0.0001475505,0.00006084919,0.0002165712,0.003171175,0.00002730872,0.005727715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009329039,"threshold_uncertainty_score":0.00312084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006406821140984089,"score_gpt":0.2729013811906126,"score_spread":0.2664945600496286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}