{"id":"W2166628585","doi":"10.4049/jimmunol.177.6.3893","title":"Strong TCR Conservation and Altered T Cell Cross-Reactivity Characterize a B*57-Restricted Immune Response in HIV-1 Infection","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital; University of Toronto; University of Manitoba","funders":"Wellcome Trust","keywords":"Epitope; Biology; T-cell receptor; Immune system; Hypervariable region; T cell; CD8; Cytotoxic T cell; Mutation; B cell; Genetics; Immunology; Antigen; Virology; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001116057,0.0001907048,0.0003659304,0.0003861776,0.0002107424,0.00003307517,0.0001612088,0.0002799716,0.0002329653],"category_scores_gemma":[0.0002311349,0.0001462531,0.00009631263,0.0002205327,0.0002962334,0.0004607294,0.00006824375,0.0009289781,0.00007930537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000150413,"about_ca_system_score_gemma":0.00009426907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001413717,"about_ca_topic_score_gemma":0.00004002947,"domain_scores_codex":[0.9972981,0.001409516,0.000819953,0.0001365972,0.00004612312,0.0002896716],"domain_scores_gemma":[0.9980148,0.0006356551,0.0008962021,0.0002297727,0.0002131189,0.00001041792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01408844,0.0002388172,0.01097738,0.000006321011,0.00007479138,0.000004774258,0.0002206603,0.00004291553,0.9730185,0.00004838748,0.0005521577,0.0007269195],"study_design_scores_gemma":[0.003256014,0.0007398526,0.8092913,0.00003509879,0.00004228683,0.0008942821,0.0001428488,0.00002568368,0.1709493,0.00004259239,0.01446334,0.0001174406],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935698,0.002247495,0.0004188978,0.0007901366,0.002546319,0.0002045365,0.000004312792,0.0000237213,0.0001947892],"genre_scores_gemma":[0.9972155,0.0004515189,0.00001454381,0.00007264964,0.00006011847,0.000007813902,0.00004149639,0.00001559571,0.002120733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8020692,"threshold_uncertainty_score":0.596403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0117127136931519,"score_gpt":0.2376977290270335,"score_spread":0.2259850153338816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}