{"id":"W2166657167","doi":"","title":"Limited penetration of anticancer drugs through tumor tissue: a potential cause of resistance of solid tumors to chemotherapy.","year":2002,"lang":"en","type":"article","venue":"PubMed","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":516,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Extracellular matrix; Cancer research; Laminin; Paclitaxel; Etoposide; Cancer cell; Chemotherapy; Medicine; Pathology; Pharmacology; Cancer; Biology; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002391202,0.0001217225,0.0004352021,0.0001686542,0.0000190826,0.000004505326,0.0001479075,0.00005032022,0.000361986],"category_scores_gemma":[0.0002665214,0.0001128562,0.00008144334,0.0006053107,0.0001427413,0.00005965013,0.00004000873,0.0001100143,0.000007820959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005996745,"about_ca_system_score_gemma":0.00004403584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006793745,"about_ca_topic_score_gemma":0.00001888936,"domain_scores_codex":[0.9980828,0.00005394797,0.0005148673,0.0002495639,0.0007721724,0.0003266631],"domain_scores_gemma":[0.998856,0.00005437566,0.0002053992,0.0004182921,0.0003259254,0.0001400237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002379289,0.001161462,0.00266291,0.001181134,0.0002211498,0.0001078006,0.003283461,0.00004464644,0.942228,0.0001187394,0.01169411,0.03491726],"study_design_scores_gemma":[0.001510129,0.0001720535,0.1811817,0.00009239079,0.0000477891,0.000007639881,0.0001252338,0.000112938,0.8153753,0.00003204928,0.001245022,0.00009773058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932608,0.0004358582,0.0002828135,0.001610351,0.00004620743,0.001354808,0.00002792138,0.00001852076,0.002962747],"genre_scores_gemma":[0.9941238,0.0001769354,0.00101533,0.0002099891,0.00005722159,0.0001634796,0.000005879481,0.00002877596,0.0042186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1785188,"threshold_uncertainty_score":0.4602142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03052564190030398,"score_gpt":0.2940063006131893,"score_spread":0.2634806587128853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}