{"id":"W2166662937","doi":"10.1056/nejmoa1504030","title":"Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma","year":2015,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":8144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"National Cancer Institute","keywords":"Nivolumab; Ipilimumab; Medicine; Melanoma; Oncology; Metastatic melanoma; Internal medicine; Dermatology; Immunotherapy; Cancer research; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001482531,0.0006086729,0.00187591,0.0004906123,0.0002493568,0.0005792086,0.0005276426,0.0005856596,0.002273006],"category_scores_gemma":[0.001412981,0.0003716011,0.0009536662,0.000328609,0.0003929242,0.0005320949,0.0003661099,0.001173271,0.0004077682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008348993,"about_ca_system_score_gemma":0.0008924744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007281049,"about_ca_topic_score_gemma":0.002115632,"domain_scores_codex":[0.999209,0.0004334119,0.0000577395,0.0001392918,0.00007499525,0.00008549343],"domain_scores_gemma":[0.9993683,0.000243364,0.00009973144,0.00004877726,0.0000219767,0.0002180403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7041777,0.01581324,0.01238966,0.001430641,0.004382761,0.0003363854,0.0002735594,0.004265074,0.03142558,0.0003260285,0.001353869,0.2238256],"study_design_scores_gemma":[0.2191222,0.7053751,0.0472942,0.0003355589,0.003566604,0.0006300131,0.0001313026,0.004712111,0.01048754,0.0008909121,0.007379352,0.00007518422],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918087,0.006034349,0.0002614172,0.0001446865,0.0001722692,0.000223571,0.0001153409,0.00002465508,0.001215019],"genre_scores_gemma":[0.9964864,0.001733206,0.0004968474,0.0001903979,0.0001417978,0.0002034989,0.0001489611,0.000007029363,0.0005917201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002273006,"threshold_uncertainty_score":0.007840455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03693018645658255,"score_gpt":0.2979048351264862,"score_spread":0.2609746486699037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}