{"id":"W2166663076","doi":"10.1016/j.biopsych.2014.05.023","title":"Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk","year":2014,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":609,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; National Institutes of Health; National Institute of Environmental Health Sciences; Commonwealth of Massachusetts","keywords":"Psychosis; Antipsychotic; Neuroimaging; Medicine; Magnetic resonance imaging; Psychology; Orbitofrontal cortex; Schizophrenia (object-oriented programming); Drug-naïve; Internal medicine; Psychiatry; Cardiology; Prefrontal cortex; Cognition; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009270108,0.0002471421,0.000609083,0.0001478316,0.0001297814,0.00001409708,0.0001516903,0.0002213514,0.00009083763],"category_scores_gemma":[0.001175964,0.0001583289,0.0001624741,0.0004643166,0.0002720133,0.00004060289,0.00012274,0.0007473356,0.00007601299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007021547,"about_ca_system_score_gemma":0.0001003427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002092985,"about_ca_topic_score_gemma":0.0001677902,"domain_scores_codex":[0.9966424,0.0009529068,0.0008160595,0.0007766277,0.0003833449,0.0004287305],"domain_scores_gemma":[0.9986179,0.0002503363,0.0002561813,0.000423799,0.0001523994,0.0002993234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01661851,0.005691091,0.9716008,0.00001818016,0.000151414,0.00004912368,0.000164957,0.00000139883,0.00009341317,0.0001268793,0.00005391609,0.005430272],"study_design_scores_gemma":[0.009781234,0.006959313,0.9811732,0.0001068383,0.0001401024,0.0001124873,0.000819153,0.0001321356,0.00003980817,0.0005715979,0.000007895628,0.0001562687],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970557,0.0002992131,0.00003381499,0.0006412156,0.0006351264,0.00116401,0.000008108423,0.00007691573,0.00008589084],"genre_scores_gemma":[0.9952189,0.00008538156,0.004212617,0.00006398716,0.0002692854,0.0000782881,0.00003982809,0.00001691866,0.00001483702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009572326,"threshold_uncertainty_score":0.6456467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08039812353853536,"score_gpt":0.3914641832431427,"score_spread":0.3110660597046074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}