{"id":"W2166663556","doi":"10.4049/jimmunol.177.1.501","title":"The Meningococcal Vaccine Candidate GNA1870 Binds the Complement Regulatory Protein Factor H and Enhances Serum Resistance","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":392,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Sanofi","keywords":"Neisseria meningitidis; Factor H; Biology; Mutant; Meningococcal vaccine; Binding protein; Microbiology; Plasma protein binding; Complement system; Bacteria; Chemistry; Molecular biology; Gene; Biochemistry; Antibody; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00084682,0.0001590744,0.0002635829,0.00005454226,0.001024721,0.00003751374,0.0004151586,0.000108998,0.0001896373],"category_scores_gemma":[0.00004120055,0.00006668892,0.00006955566,0.0001071569,0.0003275074,0.00008318189,0.0001195228,0.0004615054,0.00001455658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003802831,"about_ca_system_score_gemma":0.00005875602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002921739,"about_ca_topic_score_gemma":0.001456487,"domain_scores_codex":[0.9983923,0.0006322665,0.0005376849,0.00009731307,0.00002898301,0.000311491],"domain_scores_gemma":[0.99866,0.000333628,0.0005426633,0.0003104264,0.0001434152,0.000009833369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008005337,0.00003746873,0.0006585326,0.000003927044,0.0003204441,8.379811e-7,0.0002387267,0.00000169964,0.9898056,0.002531992,0.003880953,0.001719286],"study_design_scores_gemma":[0.002222745,0.0006293416,0.2625242,0.00006493527,0.0001124493,0.0005843425,0.0007687259,8.704702e-7,0.3550828,0.0016923,0.3761403,0.0001769699],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753028,0.01657838,0.00003792081,0.006915223,0.0007785439,0.0002369511,0.00001519637,0.00001234691,0.0001226376],"genre_scores_gemma":[0.9967096,0.0007256625,0.0000126247,0.00004344693,0.0001505949,0.00001057789,0.000003076362,0.000010516,0.002333906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6347228,"threshold_uncertainty_score":0.7881432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007543307297023139,"score_gpt":0.228141091505404,"score_spread":0.2205977842083809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}