{"id":"W2166663556","doi":"10.4049/jimmunol.177.1.501","title":"The Meningococcal Vaccine Candidate GNA1870 Binds the Complement Regulatory Protein Factor H and Enhances Serum Resistance","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":392,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Sanofi","keywords":"Neisseria meningitidis; Factor H; Biology; Mutant; Meningococcal vaccine; Binding protein; Microbiology; Plasma protein binding; Complement system; Bacteria; Chemistry; Molecular biology; Gene; Biochemistry; Antibody; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001017728,0.0003196531,0.0001737528,0.0001018397,0.00006729556,0.00017699,0.00015197,0.0001905648,0.0009317638],"category_scores_gemma":[0.00009234563,0.00006718239,0.0001242193,0.00005415622,0.000119751,0.00007755459,0.0001689777,0.0002890672,0.0002293641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002335922,"about_ca_system_score_gemma":0.0001415253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007063097,"about_ca_topic_score_gemma":0.0009969766,"domain_scores_codex":[0.9999241,0.0000170093,0.000004087452,0.000009904496,0.00002455999,0.00002044443],"domain_scores_gemma":[0.9999577,0.000007287945,0.000009520759,0.000004046152,0.000004882892,0.00001656395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004288598,0.0000162524,0.0001280353,0.000006952652,0.000001600439,0.00001228016,0.000002512509,0.00003042246,0.999292,0.00002496146,0.000009902295,0.0004321492],"study_design_scores_gemma":[0.000009867208,0.0004839107,0.003445472,0.000002393265,0.000008433392,0.0001144069,0.00001249208,0.0005636037,0.9942176,0.00001803207,0.001121799,0.000002052044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985719,0.0002148807,0.0006556673,0.00003740225,0.000006457462,0.0000095048,0.00005404664,0.00001835783,0.0004319074],"genre_scores_gemma":[0.9972398,0.0001581186,0.001092038,0.00002927241,0.000002972359,0.00000629336,0.0001716878,0.000006356393,0.001293402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009317638,"threshold_uncertainty_score":0.003117085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007543307297023139,"score_gpt":0.228141091505404,"score_spread":0.2205977842083809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}