{"id":"W2166671813","doi":"10.1373/clinchem.2005.050831","title":"Liquid Chromatography–Tandem Mass Spectrometry Analysis of Erythrocyte Thiopurine Nucleotides and Effect of Thiopurine Methyltransferase Gene Variants on These Metabolites in Patients Receiving Azathioprine/6-Mercaptopurine Therapy","year":2005,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Thiopurine methyltransferase; Chemistry; Chromatography; Mercaptopurine; High-performance liquid chromatography; Selected reaction monitoring; Azathioprine; Tandem mass spectrometry; Pharmacology; Mass spectrometry; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004835782,0.0003037155,0.0004818235,0.0008061397,0.000249767,0.0003968206,0.000260976,0.0005181429,0.0005912419],"category_scores_gemma":[0.001209005,0.0001450773,0.0003115548,0.0007263771,0.0001775663,0.0001350798,0.0001163683,0.0005026234,0.0002272053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002998387,"about_ca_system_score_gemma":0.0001670703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009747252,"about_ca_topic_score_gemma":0.0009484392,"domain_scores_codex":[0.9994567,0.0001113228,0.00004857963,0.0001538807,0.0001880846,0.00004134468],"domain_scores_gemma":[0.9994537,0.0001747484,0.0001703411,0.00002787813,0.0001148111,0.00005842746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003362479,0.0003753695,0.7084879,0.0001327814,0.000539198,0.001375746,0.0003520954,0.0006590289,0.248072,0.00009100443,0.0004658704,0.03608659],"study_design_scores_gemma":[0.00009315967,0.001211228,0.9288885,0.00002261374,0.0002772255,0.004415543,0.0001103884,0.003902789,0.05990173,0.0000751673,0.001081483,0.00002010842],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997295,0.001171315,0.0008188036,0.00005259816,0.0000147032,0.00001643025,0.0002832118,0.00003103111,0.0003170107],"genre_scores_gemma":[0.997933,0.0002305635,0.001251914,0.00008426645,0.00001363785,0.00001909194,0.0002215616,0.000006031135,0.0002398722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009747252,"threshold_uncertainty_score":0.002557397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01526527617956834,"score_gpt":0.3155000560387425,"score_spread":0.3002347798591742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}