{"id":"W2166672736","doi":"10.1177/1087057111416659","title":"Development of Homogeneous Nonradioactive Methyltransferase and Demethylase Assays Targeting Histone H3 Lysine 4","year":2011,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"PerkinElmer Biosignal","funders":"","keywords":"Demethylase; Histone methyltransferase; Epigenetics; Histone H3; Histone; Methyltransferase; Histone methylation; Biology; Biochemistry; Chromatin; EZH2; Histone H2A; Methylation; DNA methylation; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002806939,0.001550701,0.001033175,0.001503965,0.0004932849,0.0009295262,0.001759384,0.0007769624,0.001672415],"category_scores_gemma":[0.001802294,0.001332059,0.0006328317,0.0008142905,0.0008956032,0.0007491876,0.0009084516,0.001962873,0.001653238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001411892,"about_ca_system_score_gemma":0.00125004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00181963,"about_ca_topic_score_gemma":0.006553801,"domain_scores_codex":[0.9981792,0.0004854195,0.0001166193,0.0004539077,0.0005005008,0.0002643644],"domain_scores_gemma":[0.9984946,0.000555801,0.000208313,0.000237739,0.0002824744,0.0002211208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000692879,0.0000534522,0.0001702116,0.00004428441,0.00001652712,0.00001619717,0.00001900621,0.0001853358,0.9955664,0.0003698969,0.00009352221,0.003395855],"study_design_scores_gemma":[0.00001385697,0.00006835902,0.0002244445,0.00000228197,0.00001776208,0.0000311448,0.000007391658,0.00128527,0.9972348,0.00008678182,0.001021095,0.000006974934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2872665,0.001568066,0.7018694,0.0003390069,0.0001651703,0.0009315262,0.001015045,0.003148995,0.003696299],"genre_scores_gemma":[0.4734247,0.001253456,0.5113237,0.0001971602,0.00006670622,0.000902205,0.004134665,0.0004522144,0.008245151],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002806939,"threshold_uncertainty_score":0.01484466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02127013804999414,"score_gpt":0.2572365118715693,"score_spread":0.2359663738215751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}