{"id":"W2166672736","doi":"10.1177/1087057111416659","title":"Development of Homogeneous Nonradioactive Methyltransferase and Demethylase Assays Targeting Histone H3 Lysine 4","year":2011,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"PerkinElmer Biosignal","funders":"","keywords":"Demethylase; Histone methyltransferase; Epigenetics; Histone H3; Histone; Methyltransferase; Histone methylation; Biology; Biochemistry; Chromatin; EZH2; Histone H2A; Methylation; DNA methylation; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003269959,0.0001742858,0.0002005214,0.00006293065,0.00008424569,0.00001304259,0.00009956166,0.0001175264,0.00001931705],"category_scores_gemma":[0.00007726234,0.0001670786,0.0000727877,0.00007960202,0.00009920411,0.00001196889,0.00007047418,0.00006866885,0.000002077218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001998477,"about_ca_system_score_gemma":0.000116777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004300088,"about_ca_topic_score_gemma":0.00005756258,"domain_scores_codex":[0.9989254,0.00006969039,0.000326649,0.000337047,0.0001382236,0.0002029186],"domain_scores_gemma":[0.9995033,0.00001677867,0.000112773,0.0002086751,0.00007849028,0.00008002754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001151605,0.0001210097,0.00160947,0.00003080616,0.0001236801,0.000004723223,0.0007544924,0.00001542862,0.9906922,0.0001333952,0.00002449813,0.006375119],"study_design_scores_gemma":[0.0003684458,0.0001642144,0.003845755,0.00001055714,0.00004705745,0.000002334735,0.0001614655,0.0000200774,0.9923182,0.0002239336,0.002624942,0.0002130779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9430953,0.004464232,0.05093991,0.00001011394,0.0001035553,0.0001352357,0.00002590624,0.000006610492,0.001219097],"genre_scores_gemma":[0.9651966,0.0004265795,0.03393436,0.00002524423,0.00006300974,0.00001468468,0.0001033993,0.00002503879,0.0002110603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02210129,"threshold_uncertainty_score":0.6813268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02127013804999414,"score_gpt":0.2572365118715693,"score_spread":0.2359663738215751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}