{"id":"W2166678252","doi":"10.1016/s1470-2045(11)70286-8","title":"Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial","year":2011,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":703,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; University of Alberta","funders":"GlaxoSmithKline","keywords":"Medicine; Cervical cancer; Vaccine efficacy; Cervical intraepithelial neoplasia; Serostatus; Clinical endpoint; Surrogate endpoint; Clinical trial; Randomized controlled trial; Internal medicine; Gynecology; Vaccination; Oncology; Cancer; Immunology; Viral load; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001657805,0.0002435785,0.002193229,0.000323137,0.00007035159,0.000005768485,0.0006995525,0.0002409828,0.01165668],"category_scores_gemma":[0.0003774727,0.0001154544,0.0005814256,0.001385856,0.0002940957,0.00003305132,0.0002793418,0.0006435977,0.000009529968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001388209,"about_ca_system_score_gemma":0.0004247695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001235613,"about_ca_topic_score_gemma":0.001716778,"domain_scores_codex":[0.9966671,0.0008207504,0.001038152,0.0003604683,0.0006305869,0.0004828946],"domain_scores_gemma":[0.9971521,0.0009517869,0.0004686808,0.0009687831,0.0003240774,0.0001345729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9497331,0.002636661,0.0259718,0.0001066114,0.003015579,0.00003523371,0.002589253,0.00001819835,0.0003282567,0.0001217297,0.0005542061,0.01488934],"study_design_scores_gemma":[0.5898938,0.004604142,0.3981169,0.00001009251,0.003719738,0.000007224955,0.0003261313,0.0001191952,0.002397158,0.00005884232,0.0006351338,0.0001116237],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825817,0.0000948574,0.00002151419,0.0009022937,0.0003015153,0.002758748,0.00006170924,0.00002192693,0.0132557],"genre_scores_gemma":[0.9983146,0.0002004891,0.00006312037,0.0002944966,0.0008126446,0.00009000251,0.00002816026,0.00002524699,0.0001712164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3721451,"threshold_uncertainty_score":0.9892468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1649345748730365,"score_gpt":0.3985953032546488,"score_spread":0.2336607283816123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}