{"id":"W2166678252","doi":"10.1016/s1470-2045(11)70286-8","title":"Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial","year":2011,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":703,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; University of Alberta","funders":"GlaxoSmithKline","keywords":"Medicine; Cervical cancer; Vaccine efficacy; Cervical intraepithelial neoplasia; Serostatus; Clinical endpoint; Surrogate endpoint; Clinical trial; Randomized controlled trial; Internal medicine; Gynecology; Vaccination; Oncology; Cancer; Immunology; Viral load; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004519078,0.002705588,0.006466555,0.0005013652,0.0003571179,0.001581082,0.001843829,0.002545394,0.005301769],"category_scores_gemma":[0.005078624,0.001066892,0.004866011,0.0005223685,0.001713953,0.001918257,0.0007785725,0.004106355,0.001068774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009862027,"about_ca_system_score_gemma":0.001226762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00112087,"about_ca_topic_score_gemma":0.001166,"domain_scores_codex":[0.9965593,0.002369581,0.0001547898,0.0004644886,0.0001516207,0.0003002036],"domain_scores_gemma":[0.9977407,0.000865572,0.0005620901,0.0003798424,0.0001367537,0.0003150142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.991995,0.000465645,0.0002666397,0.000374499,0.001329345,0.00001632658,0.00002149669,0.0002952621,0.0006845058,0.0000509103,0.0001863991,0.004314092],"study_design_scores_gemma":[0.95166,0.04235108,0.002302308,0.00004344767,0.002142433,0.00003340229,0.00001540203,0.0005491232,0.000361342,0.0002120557,0.0003114364,0.0000180247],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862615,0.005927368,0.001151706,0.0006590107,0.0005249794,0.001731599,0.00124355,0.0002012981,0.00229898],"genre_scores_gemma":[0.9891714,0.001893996,0.001398911,0.0005536641,0.0004191294,0.002045168,0.00110443,0.00004640089,0.003366876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006466555,"threshold_uncertainty_score":0.02389944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1649345748730365,"score_gpt":0.3985953032546488,"score_spread":0.2336607283816123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}