{"id":"W2166687668","doi":"10.1093/toxsci/kfr024","title":"The Implications of DNA Methylation for Toxicology: Toward Toxicomethylomics, the Toxicology of DNA Methylation","year":2011,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research; McGill University","keywords":"DNA methylation; DNA; Carcinogen; Ames test; Biology; Mutagenesis; Genetics; Methylation; Epigenetics; Toxicology; Molecular biology; Computational biology; Gene; Mutation; Bacteria; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002829626,0.0001787458,0.0002746171,0.00007188732,0.0005069313,0.00002530702,0.0008343885,0.0003163776,0.00004655314],"category_scores_gemma":[0.001372808,0.00010191,0.0002000333,0.0004183773,0.00142808,0.00001392787,0.0001967125,0.0001067776,0.000001975983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002461039,"about_ca_system_score_gemma":0.0001428966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001461796,"about_ca_topic_score_gemma":0.0001131679,"domain_scores_codex":[0.9979243,0.0003777241,0.000660271,0.000441811,0.0002135258,0.0003823573],"domain_scores_gemma":[0.9978932,0.0007950908,0.0005532014,0.0004105963,0.0002727638,0.00007513006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009340623,0.0001453643,0.002375294,0.000008581444,0.00003851106,5.301313e-8,0.0001861439,0.0001084602,0.9565483,0.0237297,0.0001305077,0.01663567],"study_design_scores_gemma":[0.0002704943,0.002090387,0.07289189,0.000002993751,0.00004222506,0.000001142083,0.0002682926,0.0001418303,0.8857958,0.0329254,0.005428098,0.0001414245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745201,0.001441662,0.01723494,0.001965022,0.0003922247,0.0008906588,0.00003729355,0.00001420359,0.003503883],"genre_scores_gemma":[0.9940889,0.0004891891,0.004815412,0.0001751378,0.000133236,0.0001641346,0.00001967001,0.000009817637,0.0001045236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07075249,"threshold_uncertainty_score":0.5261819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0963871274772228,"score_gpt":0.3362439821849152,"score_spread":0.2398568547076924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}