{"id":"W2166730438","doi":"10.1126/science.aac4223","title":"HIV-1 neutralizing antibodies induced by native-like envelope trimers","year":2015,"lang":"en","type":"article","venue":"Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":524,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Public Health Service; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; International AIDS Vaccine Initiative; National Institute of General Medical Sciences; Aids Fonds; McKnight Foundation; National Cancer Institute; United States Agency for International Development; National Institutes of Health; Bill and Melinda Gates Foundation","keywords":"Immunogen; Epitope; Antibody; Virology; Glycoprotein; Biology; Human immunodeficiency virus (HIV); Neutralizing antibody; AIDS Vaccines; Virus; Immunology; Genetics; Monoclonal antibody; Vaccine trial","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003525426,0.0001998078,0.0001803206,0.0001894389,0.00009542874,0.0003839601,0.0001540503,0.0003570498,0.002824987],"category_scores_gemma":[0.0003235605,0.0001640374,0.0002266718,0.00005531369,0.0002214738,0.0003151198,0.0001741477,0.001104169,0.0006445288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003984894,"about_ca_system_score_gemma":0.0001286679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001540868,"about_ca_topic_score_gemma":0.0002630815,"domain_scores_codex":[0.999854,0.00003994362,0.000007611954,0.00001918718,0.00004901903,0.00003022349],"domain_scores_gemma":[0.9999198,0.00002249112,0.0000131152,0.00001207341,0.00001812522,0.00001442254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009477685,0.0003831674,0.001788732,0.0002884552,0.00008484038,0.0003792518,0.00006752025,0.0003229208,0.9072909,0.004550905,0.008671245,0.07522442],"study_design_scores_gemma":[0.0004883105,0.003058895,0.02889052,0.0001708615,0.0002106475,0.004641939,0.0001622968,0.002469721,0.8324683,0.008055945,0.1193584,0.00002404675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.859304,0.06217349,0.01098436,0.01259658,0.003547368,0.0001685228,0.0004615484,0.0006759019,0.05008817],"genre_scores_gemma":[0.9693396,0.01046162,0.002428506,0.005044879,0.0006006621,0.00004257374,0.0002423481,0.00005065477,0.01178922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002824987,"threshold_uncertainty_score":0.009450555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05496092498174045,"score_gpt":0.3235306648220663,"score_spread":0.2685697398403258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}