{"id":"W2166733691","doi":"10.1093/jac/dku199","title":"Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity","year":2014,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"ViiV Healthcare; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Dolutegravir; Elvitegravir; Raltegravir; Integrase; Integrase inhibitor; Virology; Biology; Viral replication; Virus; Viral load; Human immunodeficiency virus (HIV); Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002893495,0.0006262932,0.0006465643,0.0002580195,0.0001840903,0.0004361604,0.0006189573,0.0006223103,0.00440787],"category_scores_gemma":[0.0004751549,0.0002289398,0.0004802771,0.000282217,0.0004533358,0.0002406972,0.0002819359,0.001162196,0.0008691475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005385948,"about_ca_system_score_gemma":0.0004839003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001517199,"about_ca_topic_score_gemma":0.001512735,"domain_scores_codex":[0.9996104,0.00006036576,0.00006354091,0.00006033249,0.0001421801,0.00006329837],"domain_scores_gemma":[0.9996632,0.00009028344,0.0001066291,0.00003770299,0.00002653025,0.000075585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006444828,0.0003227573,0.0003964762,0.00006965407,0.00003641343,0.0002113094,0.00001832429,0.000416368,0.9949248,0.00009888479,0.0001224106,0.002738183],"study_design_scores_gemma":[0.0001779545,0.002145226,0.002243892,0.00001517099,0.0000529616,0.001247004,0.0000340437,0.001637381,0.9898779,0.00005380388,0.002499903,0.00001482666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969869,0.0005284365,0.0006268771,0.0001254179,0.00004717496,0.00004841371,0.0002912573,0.00009868093,0.001246858],"genre_scores_gemma":[0.9965249,0.0003358031,0.001126293,0.00007349902,0.00001519237,0.00002510777,0.0004099583,0.00005173986,0.001437519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00440787,"threshold_uncertainty_score":0.01474583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01078952885662238,"score_gpt":0.2491333081583089,"score_spread":0.2383437793016866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}