{"id":"W2166761612","doi":"10.1093/toxsci/kfh010","title":"Human Interindividual Variation in Lymphocyte UDP-Glucuronosyltransferases as a Determinant of In Vitro Benzo[a]pyrene Covalent Binding and Cytotoxicity","year":2003,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Glucuronidation; Chemistry; Carcinogen; UGT2B7; Cytotoxicity; Glucuronosyltransferase; Microsome; Benzo(a)pyrene; Xenobiotic; In vitro; Biochemistry; Isozyme; Population; Pyrene; Pharmacology; Enzyme; Biology; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00248009,0.0002354443,0.0004430665,0.0003180385,0.0002383504,0.00003466155,0.0003443281,0.0002540592,0.0006092543],"category_scores_gemma":[0.0002387001,0.0001936423,0.00006692632,0.0006046785,0.0007078596,0.0001481957,0.0001075863,0.0003604433,0.000009263411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009478387,"about_ca_system_score_gemma":0.0001382609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008597779,"about_ca_topic_score_gemma":0.00008401179,"domain_scores_codex":[0.9971629,0.0008655955,0.0006156533,0.0005161621,0.0002547875,0.0005848444],"domain_scores_gemma":[0.9991286,0.0003953415,0.0001559514,0.00009432879,0.00002771407,0.0001980325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001343777,0.0005987231,0.02344154,0.00002203133,0.00001351866,0.00004587614,0.0006638779,0.0004676206,0.9660476,0.002542956,0.000003753814,0.006018121],"study_design_scores_gemma":[0.002541105,0.0006196999,0.1104094,0.00002397013,0.00004080796,0.00003488972,0.000189911,0.00125338,0.8816937,0.002036409,0.0008546433,0.0003020702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963731,0.0006837582,0.00002970953,0.0001190752,0.0003111775,0.0004303072,0.00004141813,0.00002125111,0.001990179],"genre_scores_gemma":[0.9985436,0.0004539118,0.0003969413,0.0004814639,0.00003086958,0.00005532507,0.000002823443,0.000007000613,0.00002807392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08696789,"threshold_uncertainty_score":0.7896504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1425561427474743,"score_gpt":0.4361603760266812,"score_spread":0.2936042332792069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}