{"id":"W2166761612","doi":"10.1093/toxsci/kfh010","title":"Human Interindividual Variation in Lymphocyte UDP-Glucuronosyltransferases as a Determinant of In Vitro Benzo[a]pyrene Covalent Binding and Cytotoxicity","year":2003,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Glucuronidation; Chemistry; Carcinogen; UGT2B7; Cytotoxicity; Glucuronosyltransferase; Microsome; Benzo(a)pyrene; Xenobiotic; In vitro; Biochemistry; Isozyme; Population; Pyrene; Pharmacology; Enzyme; Biology; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000727592,0.0002163024,0.0003278333,0.0004128174,0.0001710821,0.0004445619,0.0001530281,0.0003224472,0.0006820773],"category_scores_gemma":[0.002016163,0.0001796824,0.0001379406,0.0004746687,0.0002765109,0.0001403371,0.0001878422,0.0002609643,0.0002024693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001222337,"about_ca_system_score_gemma":0.00005725831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007364569,"about_ca_topic_score_gemma":0.000485113,"domain_scores_codex":[0.9990752,0.0002959981,0.0000611182,0.0003665001,0.0001429382,0.00005831033],"domain_scores_gemma":[0.9990026,0.0004152659,0.0001695049,0.0002358887,0.0001010713,0.00007565631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001782763,0.0001617307,0.861472,0.00005575261,0.0005220018,0.0003969113,0.0008648822,0.0008965803,0.1101961,0.0003111681,0.0003849656,0.02295524],"study_design_scores_gemma":[0.000009414703,0.0005032512,0.9901917,0.00000364752,0.00007388793,0.0009606738,0.00008197436,0.0007852397,0.006661,0.0001611505,0.0005591651,0.000008940146],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973739,0.0005804227,0.001203139,0.0000139921,0.000006642164,0.00001287343,0.0001890806,0.00002217742,0.0005977144],"genre_scores_gemma":[0.9994366,0.00005604817,0.000164807,0.00001130741,0.000003984526,0.000006779297,0.0001580957,0.000005398621,0.0001570302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007364569,"threshold_uncertainty_score":0.003847957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1425561427474743,"score_gpt":0.4361603760266812,"score_spread":0.2936042332792069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}