{"id":"W2166774548","doi":"10.1002/eji.201444688","title":"PD‐1 is not required for natural or peripherally induced regulatory T cells: Severe autoimmunity despite normal production of regulatory T cells","year":2014,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates - Health Solutions; Multiple Sclerosis Society of Canada; Alberta Innovates; Multiple Sclerosis Society; Canadian Institutes of Health Research; Multiple Sclerosis Scientific Research Foundation","keywords":"Autoimmunity; Biology; FOXP3; Cell biology; Immune system; Immunology; Immune tolerance; T cell; IL-2 receptor; Cell; Regulatory T cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001793348,0.0004145241,0.0004872109,0.0002860484,0.0001943754,0.0005229842,0.0003387226,0.0004602899,0.001729994],"category_scores_gemma":[0.0002828236,0.0002331414,0.000223868,0.0001569022,0.0005209695,0.0003268297,0.0003269088,0.00128353,0.0006712622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002423973,"about_ca_system_score_gemma":0.0002657257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002116911,"about_ca_topic_score_gemma":0.0002714831,"domain_scores_codex":[0.9996043,0.00005938164,0.00004710992,0.0001112148,0.00009525526,0.00008291753],"domain_scores_gemma":[0.9995345,0.00007777524,0.0001400583,0.00006141565,0.00002673858,0.0001596207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001343422,0.00003850752,0.000233483,0.00003829799,0.000004074847,0.00009756391,0.000006983874,0.00004369328,0.9984292,0.00006199127,0.00003008726,0.0008817356],"study_design_scores_gemma":[0.0000637538,0.0005294588,0.008593474,0.00001865465,0.0000303104,0.002518665,0.00003773385,0.001546231,0.9835775,0.0001366849,0.002937554,0.000009938886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930317,0.002152004,0.002766835,0.0001217585,0.00004007178,0.00002051211,0.0004396235,0.0001570138,0.001270388],"genre_scores_gemma":[0.9953753,0.0005362157,0.001651712,0.00006761624,0.00001649175,0.00004076896,0.0006575469,0.00005536347,0.001599014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001729994,"threshold_uncertainty_score":0.005787432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722576182685751,"score_gpt":0.2243066204453607,"score_spread":0.2070808586185032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}