{"id":"W2166774548","doi":"10.1002/eji.201444688","title":"PD‐1 is not required for natural or peripherally induced regulatory T cells: Severe autoimmunity despite normal production of regulatory T cells","year":2014,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates - Health Solutions; Multiple Sclerosis Society of Canada; Alberta Innovates; Multiple Sclerosis Society; Canadian Institutes of Health Research; Multiple Sclerosis Scientific Research Foundation","keywords":"Autoimmunity; Biology; FOXP3; Cell biology; Immune system; Immunology; Immune tolerance; T cell; IL-2 receptor; Cell; Regulatory T cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002072358,0.0003397846,0.0006703928,0.0003824267,0.0003298597,0.00002314284,0.000578073,0.0002425479,0.0007278845],"category_scores_gemma":[0.0003880306,0.0002816437,0.0003885069,0.0001826031,0.0003953961,0.0004904784,0.0001353961,0.001056891,0.0001742534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001349672,"about_ca_system_score_gemma":0.0001786269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001205011,"about_ca_topic_score_gemma":0.000001772801,"domain_scores_codex":[0.9958406,0.001891952,0.001389653,0.0003261948,0.0001004875,0.0004511295],"domain_scores_gemma":[0.9965876,0.0001956458,0.00168418,0.0006475842,0.0008512276,0.0000337013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00671248,0.0001921226,0.0000266855,0.00005108497,0.0005306698,0.000005863889,0.001295221,0.0000364845,0.9589535,0.00007317571,0.01533325,0.01678949],"study_design_scores_gemma":[0.003304726,0.00296039,0.01116956,0.0001411961,0.0001148011,0.0008462426,0.0005635778,0.00001357353,0.8389204,0.000010143,0.1416623,0.0002931698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760634,0.001189885,0.0003761777,0.0004659883,0.02081286,0.000283327,0.000004870762,0.00005372036,0.0007498048],"genre_scores_gemma":[0.9785475,0.0001331305,0.0005562282,0.0005440177,0.0002558336,0.00000342818,0.00002217591,0.00006548452,0.01987216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.126329,"threshold_uncertainty_score":0.9999636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722576182685751,"score_gpt":0.2243066204453607,"score_spread":0.2070808586185032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}