{"id":"W2166798619","doi":"10.4049/jimmunol.177.2.896","title":"Suppression of Antitumor Immunity by IL-10 and TGF-β-Producing T Cells Infiltrating the Growing Tumor: Influence of Tumor Environment on the Induction of CD4+ and CD8+ Regulatory T Cells","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":433,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"IL-2 receptor; FOXP3; Cytotoxic T cell; CD8; Biology; CTL*; Cytokine; Interleukin 21; Cancer research; Tumor microenvironment; Immune system; Regulatory T cell; Immunology; T cell; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001897427,0.0002555097,0.0006036312,0.0001452471,0.0003855705,0.000007956097,0.0005893955,0.00017852,0.00009289067],"category_scores_gemma":[0.0001223563,0.0001367613,0.0001066845,0.0001327222,0.002333335,0.0002117219,0.0002894185,0.0009771482,0.000005986957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003338513,"about_ca_system_score_gemma":0.00006391188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000491308,"about_ca_topic_score_gemma":0.000003562841,"domain_scores_codex":[0.9969318,0.00134301,0.001103412,0.0001907729,0.0001079783,0.0003230081],"domain_scores_gemma":[0.9963964,0.001024926,0.001822804,0.0006133693,0.0001300377,0.0000125124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006173712,0.0001927505,0.0004716017,0.00003733468,0.0002109561,0.000002324032,0.0008993442,0.0004110831,0.9960321,0.0002402993,0.0004637719,0.0004210169],"study_design_scores_gemma":[0.0009676728,0.0009632146,0.01413872,0.0001780966,0.0001328199,0.0004944013,0.002062075,0.000003439749,0.9796917,0.0002485489,0.0009970739,0.0001222292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890544,0.009752823,0.00001074562,0.0004997855,0.0003569393,0.0002375596,0.00002132392,0.000006352197,0.00006006088],"genre_scores_gemma":[0.9987084,0.0009506559,0.00003990291,0.00008313246,0.00002920308,0.000002792696,0.000004033065,0.00001740221,0.0001644766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01634044,"threshold_uncertainty_score":0.859727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006617329149013195,"score_gpt":0.1889218232436771,"score_spread":0.1823044940946639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}