{"id":"W2166798619","doi":"10.4049/jimmunol.177.2.896","title":"Suppression of Antitumor Immunity by IL-10 and TGF-β-Producing T Cells Infiltrating the Growing Tumor: Influence of Tumor Environment on the Induction of CD4+ and CD8+ Regulatory T Cells","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":433,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"IL-2 receptor; FOXP3; Cytotoxic T cell; CD8; Biology; CTL*; Cytokine; Interleukin 21; Cancer research; Tumor microenvironment; Immune system; Regulatory T cell; Immunology; T cell; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001943947,0.0006237389,0.0003478835,0.0001721177,0.00007241582,0.000242515,0.0001731595,0.0002135869,0.0006646563],"category_scores_gemma":[0.0001311232,0.0001504575,0.0002267822,0.00007257171,0.0002778826,0.0001842805,0.0001367554,0.0007982433,0.0001948741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001313017,"about_ca_system_score_gemma":0.0002336114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002056692,"about_ca_topic_score_gemma":0.000322673,"domain_scores_codex":[0.9998704,0.00002574004,0.00001101503,0.00002425883,0.00002531636,0.00004334121],"domain_scores_gemma":[0.9998162,0.00003334858,0.0000500739,0.00001914018,0.00001491678,0.00006631006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001491121,0.0000360842,0.0001550349,0.00001628364,0.000001749855,0.00002831947,0.000006453156,0.00003459165,0.9988581,0.00001677025,0.00000463601,0.0006928794],"study_design_scores_gemma":[0.00008623096,0.001608994,0.004225872,0.0000084188,0.0000287861,0.000263584,0.00002200441,0.001407892,0.9915957,0.00005069861,0.0006984322,0.000003451199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975473,0.0008550813,0.0009483636,0.00004973749,0.00001872441,0.00001924226,0.0000419384,0.00003993491,0.0004796778],"genre_scores_gemma":[0.9973356,0.0004926019,0.001046418,0.00005102448,0.00002830123,0.00003438829,0.00009607613,0.00001449191,0.0009009156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006646563,"threshold_uncertainty_score":0.002223492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006617329149013195,"score_gpt":0.1889218232436771,"score_spread":0.1823044940946639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}