{"id":"W2166861359","doi":"10.1517/14728222.10.2.289","title":"The emerging importance of DNA mapping and other comprehensive screening techniques, as tools to identify new drug targets and as a means of (cancer) therapy personalisation","year":2006,"lang":"en","type":"review","venue":"Expert Opinion on Therapeutic Targets","topic":"Gene expression and cancer classification","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"","keywords":"Computational biology; Personalized medicine; Drug; Drug discovery; Biology; Human genome; Precision medicine; Single-nucleotide polymorphism; Bioinformatics; Gene; Genome; Pharmacology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002383026,0.0003810817,0.0006050642,0.0001276966,0.0001601252,0.00004931952,0.0002749945,0.0002182847,0.00002831561],"category_scores_gemma":[0.00002480392,0.0002797796,0.0001934618,0.0001691391,0.0001052953,0.00001091371,0.0000787702,0.0001415421,9.776332e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002899518,"about_ca_system_score_gemma":0.0001625025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001691472,"about_ca_topic_score_gemma":0.00001304267,"domain_scores_codex":[0.9980888,0.0002110222,0.0006040569,0.0005733583,0.0002900808,0.0002326205],"domain_scores_gemma":[0.9986151,0.00007237782,0.0006633988,0.0004393659,0.0001172247,0.0000925147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001080358,0.00002789858,0.00003151593,0.0002251172,0.0001904181,2.044169e-7,0.0008006713,0.000001844772,0.03641825,0.0002031138,0.003172307,0.9588206],"study_design_scores_gemma":[0.0002875534,0.0001442232,0.0001577322,0.00153355,0.00001389256,0.000005061725,0.0004962761,0.00000541229,0.01908717,0.00008715047,0.9778958,0.0002861875],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003370969,0.9965219,0.001338338,0.0004138993,0.0002276822,0.0009658448,0.00003289521,0.00001796589,0.0001444098],"genre_scores_gemma":[0.0009693272,0.9963971,0.0007394126,0.0008867921,0.000319567,0.0002332009,0.0001138681,0.00006480906,0.0002758804],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9747235,"threshold_uncertainty_score":0.9999654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08813478646019927,"score_gpt":0.4022985804189103,"score_spread":0.314163793958711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}