{"id":"W2166889635","doi":"10.1002/prot.22754","title":"The crystal structure of ribonuclease A in complex with thymidine‐3′‐monophosphate provides further insight into ligand binding","year":2010,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"","keywords":"Bovine pancreatic ribonuclease; Isothermal titration calorimetry; RNase P; Chemistry; Stereochemistry; Ribonuclease; Pyrimidine; Dissociation constant; Ligand (biochemistry); Pancreatic ribonuclease; Thymidine; Enzyme; Moiety; Nucleic acid; Biochemistry; DNA; RNA; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174785,0.0002786194,0.0002666312,0.0001439759,0.0003795105,0.0002196451,0.0001815414,0.0001877207,0.0001866665],"category_scores_gemma":[0.00007819843,0.000150946,0.00003692234,0.000350103,0.0003409958,0.0005293799,0.0000803751,0.0004086015,0.00000351476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002451556,"about_ca_system_score_gemma":0.00007878469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009364716,"about_ca_topic_score_gemma":0.002279387,"domain_scores_codex":[0.9986003,0.00003378282,0.0005082036,0.0002184974,0.0003391775,0.0003000474],"domain_scores_gemma":[0.9990147,0.00005055831,0.0003777595,0.0003214955,0.0001362473,0.00009923291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004801445,0.00001117035,0.002753282,0.0002138107,0.00001731307,8.687765e-7,0.002530967,0.00003963576,0.9868492,0.001352201,0.00005803361,0.005693347],"study_design_scores_gemma":[0.003512889,0.001377841,0.02962644,0.0001587771,0.0001170173,0.0001566757,0.003246021,0.005100107,0.92866,0.009842956,0.0173093,0.0008920042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970066,0.00007545666,0.001074608,0.0002055115,0.0004944435,0.0007494389,0.00006796616,0.00005630793,0.0002696509],"genre_scores_gemma":[0.9858395,0.00001261552,0.01381792,0.0001129775,0.0001173859,0.00001053024,0.00003724916,0.00001987229,0.00003198514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05818925,"threshold_uncertainty_score":0.61554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006011024792459641,"score_gpt":0.197543123740865,"score_spread":0.1915320989484053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}