{"id":"W2166891849","doi":"10.1084/jem.20010032","title":"Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance","year":2002,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Immunotherapy; T cell; Cancer research; Antigen; Tumor antigen; Biology; Avidity; Immunology; Antigen presentation; Cross-presentation; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094088,0.0006075713,0.0002983809,0.0002715155,0.00008216357,0.000322748,0.0001768154,0.0003978236,0.0009784317],"category_scores_gemma":[0.0001627895,0.0001830972,0.0002264909,0.0001441897,0.0002967963,0.0003035441,0.0003285132,0.0008267486,0.000248326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615943,"about_ca_system_score_gemma":0.0001650577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002636354,"about_ca_topic_score_gemma":0.0003349137,"domain_scores_codex":[0.9997503,0.00006240497,0.00001586687,0.00004538565,0.00006120361,0.00006472698],"domain_scores_gemma":[0.9997624,0.0000711183,0.00006701059,0.00003898136,0.00001577355,0.00004481381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001069855,0.00006087685,0.00008911655,0.00001376213,0.000001742511,0.0000508202,0.000009829383,0.0001000582,0.9990791,0.00007834721,0.000007721184,0.0004015262],"study_design_scores_gemma":[0.00004458636,0.001285013,0.00122888,0.000003451429,0.0000149548,0.0003957681,0.00001282995,0.002087662,0.9941246,0.00007747234,0.0007215541,0.000003391383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979531,0.0003263411,0.0009519536,0.00002431088,0.000008261301,0.00001195539,0.00003361931,0.0000293958,0.0006611148],"genre_scores_gemma":[0.9983891,0.0002304085,0.0005667238,0.00001608222,0.000008409999,0.00001067126,0.00007681943,0.000009311374,0.0006924545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009784317,"threshold_uncertainty_score":0.003273189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05298642569239095,"score_gpt":0.3824469092774853,"score_spread":0.3294604835850943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}