{"id":"W2166895287","doi":"10.1189/jlb.72.6.1234","title":"Regulation of gene expression in mouse macrophages stimulated with bacterial CpG-DNA and lipopolysaccharide","year":2002,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of Allergy and Infectious Diseases; National Institutes of Health; American Heart Association","keywords":"TLR9; Biology; Toll-Like Receptor 9; CpG site; Innate immune system; Molecular biology; CpG Oligodeoxynucleotide; Gene; Cell biology; Gene expression; DNA methylation; Receptor; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002814111,0.0001153011,0.0003481836,0.0002690079,0.00004138904,0.000005741363,0.00009901959,0.0002430357,0.0003934638],"category_scores_gemma":[0.00007593203,0.00008103032,0.00004313643,0.00006642448,0.0001442548,0.000157931,0.00002496517,0.0001872126,0.000009221863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003549591,"about_ca_system_score_gemma":0.00002953837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001716237,"about_ca_topic_score_gemma":0.000004393317,"domain_scores_codex":[0.9988392,0.0003077638,0.0005533143,0.0001101417,0.0000273294,0.0001622311],"domain_scores_gemma":[0.9991138,0.0001106137,0.000539094,0.0001142574,0.0001067733,0.00001545073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002414881,0.00005730054,0.001569935,0.000009194744,0.00005905994,0.000007883693,0.0003162146,0.00003534514,0.9924679,0.00004150228,0.00009078881,0.002930016],"study_design_scores_gemma":[0.00299284,0.0008266929,0.009629708,0.00005609751,0.00002053549,0.0002866264,0.00004744628,0.00002790494,0.9849386,0.00003517518,0.001054009,0.00008440331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997318,0.001998539,0.0002080677,0.00009178823,0.0002510672,0.00008448418,0.000003782927,0.000006444023,0.0000377776],"genre_scores_gemma":[0.9988855,0.0004167708,0.000334167,0.00001408552,0.0000532616,0.000001756965,0.00001390455,0.000007476179,0.0002730935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008059773,"threshold_uncertainty_score":0.4308152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01168192385563745,"score_gpt":0.2226246774974728,"score_spread":0.2109427536418353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}