{"id":"W2166922847","doi":"10.1517/14728222.12.10.1289","title":"Proprotein convertases as therapeutic targets","year":2008,"lang":"en","type":"article","venue":"Expert Opinion on Therapeutic Targets","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Proprotein Convertases; Proteases; Furin; Proprotein convertase; Serine; Biology; Cancer research; Bioinformatics; Enzyme; Medicine; Pharmacology; Biochemistry; Lipoprotein; Cholesterol; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000143359,0.0004261462,0.000296962,0.00007861764,0.0003460845,0.00002580198,0.0003595208,0.0002934806,0.0006041119],"category_scores_gemma":[0.00003460947,0.0003588211,0.0002016336,0.0001027689,0.0001515433,0.0000144678,0.00008213855,0.0001941665,0.0003613265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003480797,"about_ca_system_score_gemma":0.0001665866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004129942,"about_ca_topic_score_gemma":0.000001567001,"domain_scores_codex":[0.9978719,0.0001689779,0.0003239209,0.0006979011,0.0003907278,0.0005465896],"domain_scores_gemma":[0.9988841,0.00001712079,0.0001302699,0.0006762962,0.00009994033,0.0001922545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005997838,0.0004673619,0.00004522305,0.00001091279,0.0002111726,0.00002410995,0.0005267636,0.000006447732,0.9727425,0.002205967,0.01108783,0.01207193],"study_design_scores_gemma":[0.0006958123,0.001110653,0.00004527037,0.00001064584,0.000003610586,0.00005568447,0.00006429805,0.00002576223,0.6238646,0.0007481233,0.3730358,0.0003397654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.09450538,0.8315063,0.02328028,0.009661079,0.01074198,0.009222366,0.0001907064,0.001077177,0.0198148],"genre_scores_gemma":[0.9798838,0.00535836,0.0004469723,0.01127832,0.0009221083,0.0003374118,0.0002612267,0.00009339484,0.001418357],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8853785,"threshold_uncertainty_score":0.9998864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02614505512069781,"score_gpt":0.2825770326004401,"score_spread":0.2564319774797423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}