{"id":"W2166922847","doi":"10.1517/14728222.12.10.1289","title":"Proprotein convertases as therapeutic targets","year":2008,"lang":"en","type":"article","venue":"Expert Opinion on Therapeutic Targets","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Proprotein Convertases; Proteases; Furin; Proprotein convertase; Serine; Biology; Cancer research; Bioinformatics; Enzyme; Medicine; Pharmacology; Biochemistry; Lipoprotein; Cholesterol; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004833051,0.0005155703,0.0005109405,0.0003531178,0.0001081152,0.0006112853,0.0004245725,0.0008555586,0.002603941],"category_scores_gemma":[0.0002420558,0.00008998095,0.0001837001,0.0002834969,0.0002644342,0.0005032027,0.0002151358,0.0011632,0.001148732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004222071,"about_ca_system_score_gemma":0.0002539009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001251763,"about_ca_topic_score_gemma":0.0001809984,"domain_scores_codex":[0.9998873,0.00002729892,0.000008607847,0.00001772117,0.00003988329,0.00001908444],"domain_scores_gemma":[0.9998831,0.00004464019,0.00002418577,0.00000461479,0.00002885174,0.00001458883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001341922,0.0003499434,0.0005696595,0.006467869,0.0001070905,0.002011436,0.0000914105,0.001531574,0.2008751,0.02580497,0.02366365,0.7371855],"study_design_scores_gemma":[0.0007148069,0.002094515,0.001611341,0.00125324,0.0003160218,0.007433362,0.0001203271,0.002011173,0.1262452,0.01867873,0.8394735,0.000047682],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009407405,0.9705524,0.005888935,0.004254376,0.0008100043,0.00005381708,0.00008296745,0.00007256384,0.008877495],"genre_scores_gemma":[0.08679209,0.8938221,0.006256949,0.002591835,0.001247827,0.0001190309,0.0002405181,0.00002009315,0.008909568],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002603941,"threshold_uncertainty_score":0.0087111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02614505512069781,"score_gpt":0.2825770326004401,"score_spread":0.2564319774797423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}