{"id":"W2166948233","doi":"10.1002/jor.22020","title":"PTHrP increases RANKL expression by stromal cells from giant cell tumor of bone","year":2011,"lang":"en","type":"article","venue":"Journal of Orthopaedic Research®","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"Hamilton Health Sciences Foundation; Canadian Institutes of Health Research; Hamilton Health Sciences","keywords":"Stromal cell; RANKL; Giant-cell tumor of bone; Giant cell; Osteoclast; Multinucleate; Cancer research; Parathyroid hormone; Bone resorption; Chemistry; Receptor; Biology; Pathology; Internal medicine; Endocrinology; Cell biology; Medicine; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008532445,0.0002865326,0.0002555972,0.0003036686,0.0001333811,0.0002433955,0.00006354624,0.0002073698,0.001565289],"category_scores_gemma":[0.0002131595,0.0001572074,0.0002066622,0.0001825597,0.0001864825,0.00009521278,0.0001602717,0.0003505849,0.000449616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001075231,"about_ca_system_score_gemma":0.0001099836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004971334,"about_ca_topic_score_gemma":0.0008510655,"domain_scores_codex":[0.9998739,0.00003048593,0.000008853604,0.00001657969,0.00003919013,0.00003097706],"domain_scores_gemma":[0.9998885,0.00003788552,0.00002281398,0.000009551083,0.00001171972,0.00002957458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001049519,0.00001630206,0.0006385998,0.00004460314,0.000003864395,0.000378614,0.00003852302,0.00001700021,0.9976431,0.00001213727,0.0000254253,0.001077008],"study_design_scores_gemma":[0.0001300105,0.002182595,0.04815964,0.00001241112,0.00006190736,0.01062508,0.0002403046,0.0007965541,0.9335129,0.00009364481,0.004174452,0.00001053455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964105,0.001790178,0.0007119041,0.00005045181,0.00001151076,0.00002228607,0.0000932863,0.0000239311,0.0008858982],"genre_scores_gemma":[0.9975843,0.000598232,0.0007682462,0.00002758952,0.00001717869,0.00001722498,0.0002152898,0.000006736137,0.0007652198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001565289,"threshold_uncertainty_score":0.005236387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05531703846126079,"score_gpt":0.3127461795863558,"score_spread":0.257429141125095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}