{"id":"W2166985476","doi":"10.1161/01.cir.0000062688.76508.b3","title":"In Vivo Gene Transfer of the O <sub>2</sub> -Sensitive Potassium Channel Kv1.5 Reduces Pulmonary Hypertension and Restores Hypoxic Pulmonary Vasoconstriction in Chronically Hypoxic Rats","year":2003,"lang":"en","type":"article","venue":"Circulation","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":258,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; University of Alberta","funders":"","keywords":"Hypoxic pulmonary vasoconstriction; Pulmonary hypertension; Medicine; Hypoxia (environmental); Right ventricular hypertrophy; Pulmonary artery; Vascular resistance; Vasoconstriction; Internal medicine; Lung; In vivo; Potassium channel; Muscle hypertrophy; Ex vivo; Cardiology; Endocrinology; Hemodynamics; Chemistry; Biology; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004400171,0.0001925341,0.000364039,0.0003025802,0.0000717907,0.000007666478,0.00004602327,0.0002149467,0.000005056933],"category_scores_gemma":[0.0002165345,0.0001565753,0.00009372554,0.0006311457,0.0001247285,0.0001829933,0.00001595157,0.0002554089,0.000002927009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001708445,"about_ca_system_score_gemma":0.0001431694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006204833,"about_ca_topic_score_gemma":0.00001833475,"domain_scores_codex":[0.9983432,0.0002985518,0.0004394079,0.0003723112,0.0002834166,0.0002631313],"domain_scores_gemma":[0.9993073,0.0002015575,0.00008539665,0.0002388553,0.0000909411,0.00007596763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001139404,0.0002334223,0.01622894,0.00007534718,0.00001702027,0.0001357561,0.0001369919,0.0006202014,0.9794391,0.00004285595,0.00001643148,0.002939949],"study_design_scores_gemma":[0.0008543497,0.00005157593,0.3921115,0.0002119454,0.00005902446,0.0004741719,0.00009297673,0.003547253,0.602139,0.0003226796,0.00001386142,0.0001216877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969223,0.001067144,0.0001028357,0.000373679,0.0002563087,0.0007808293,0.000005916624,0.00002200219,0.0004689817],"genre_scores_gemma":[0.9991759,0.0004493528,0.00003190919,0.0001617498,0.0001047125,0.00002867602,0.000009973645,0.00002696069,0.0000107643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3773001,"threshold_uncertainty_score":0.6384955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01504851523906455,"score_gpt":0.2191133604928844,"score_spread":0.2040648452538198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}