{"id":"W2166985476","doi":"10.1161/01.cir.0000062688.76508.b3","title":"In Vivo Gene Transfer of the O <sub>2</sub> -Sensitive Potassium Channel Kv1.5 Reduces Pulmonary Hypertension and Restores Hypoxic Pulmonary Vasoconstriction in Chronically Hypoxic Rats","year":2003,"lang":"en","type":"article","venue":"Circulation","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":258,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; University of Alberta","funders":"","keywords":"Hypoxic pulmonary vasoconstriction; Pulmonary hypertension; Medicine; Hypoxia (environmental); Right ventricular hypertrophy; Pulmonary artery; Vascular resistance; Vasoconstriction; Internal medicine; Lung; In vivo; Potassium channel; Muscle hypertrophy; Ex vivo; Cardiology; Endocrinology; Hemodynamics; Chemistry; Biology; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002639091,0.0006865727,0.0004489528,0.0004295539,0.0001718335,0.0003130044,0.0004231812,0.0004551191,0.001643894],"category_scores_gemma":[0.0001374481,0.0002242249,0.0004349105,0.0001548109,0.0006626492,0.0004261331,0.0002021857,0.0008122888,0.00033841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004764257,"about_ca_system_score_gemma":0.0004237876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001079294,"about_ca_topic_score_gemma":0.001490316,"domain_scores_codex":[0.999768,0.00002436278,0.00002560727,0.00005839518,0.00002898553,0.00009474597],"domain_scores_gemma":[0.9996392,0.00002909612,0.0001649569,0.00002926055,0.00002377219,0.0001138157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000695566,0.0002634059,0.0002249039,0.000041302,0.00001221186,0.00003776713,0.00002110041,0.0001082467,0.997092,0.0001098659,0.00005845595,0.001335111],"study_design_scores_gemma":[0.0002091326,0.004766418,0.00383244,0.00001443899,0.00007717913,0.0001713927,0.00006927099,0.001019391,0.9886889,0.00007087814,0.001070656,0.000009993375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995963,0.0004177545,0.002483729,0.0001283308,0.000060715,0.00004409135,0.0002741186,0.0001578892,0.0004704308],"genre_scores_gemma":[0.9925485,0.0005887341,0.003177656,0.0001037655,0.00003445272,0.0001083428,0.0005862981,0.00006274208,0.002789563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001643894,"threshold_uncertainty_score":0.005499363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01504851523906455,"score_gpt":0.2191133604928844,"score_spread":0.2040648452538198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}