{"id":"W2167061320","doi":"10.1074/jbc.m508210200","title":"TRP-ML1 Is a Lysosomal Monovalent Cation Channel That Undergoes Proteolytic Cleavage","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Transient receptor potential channel; Chemistry; Cleavage (geology); Cell biology; Biochemistry; Biophysics; Biology; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003443446,0.0002026491,0.0002816992,0.00002727385,0.00006903881,0.00003138633,0.0002872337,0.0003105154,0.0001820536],"category_scores_gemma":[0.0001487457,0.0001465274,0.0002871504,0.00007269841,0.0001061817,0.000008498098,0.00008260841,0.000258493,0.00001189512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003508895,"about_ca_system_score_gemma":0.00007129772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002155172,"about_ca_topic_score_gemma":5.300188e-7,"domain_scores_codex":[0.9987887,0.00004717302,0.0004258789,0.0002655918,0.0002067312,0.0002659327],"domain_scores_gemma":[0.999099,0.00002060203,0.0003714346,0.0002200488,0.0001253935,0.000163549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002320198,0.0001620561,0.0004815679,0.00002371964,0.00006851082,0.000008500281,0.00004103913,0.0000497081,0.9935427,0.000004024235,0.003360517,0.002025668],"study_design_scores_gemma":[0.0007265822,0.0002183766,0.002137923,0.00002990581,0.00003412728,0.0002370013,0.00009824761,0.00006132624,0.9767208,0.000131597,0.01940324,0.0002008392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994348,0.003052499,0.0007869003,0.000982196,0.0001068535,0.00008954168,0.00001258114,0.00001159938,0.0006097896],"genre_scores_gemma":[0.995948,0.0005577834,0.0006421624,0.0007387004,0.001527483,0.000005937937,0.00001845106,0.00001539874,0.0005461135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01682183,"threshold_uncertainty_score":0.5975214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03044278848277428,"score_gpt":0.2604415694593673,"score_spread":0.229998780976593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}