{"id":"W2167091449","doi":"10.1074/jbc.c500140200","title":"Mitochondrial Cyclic AMP Response Element-binding Protein (CREB) Mediates Mitochondrial Gene Expression and Neuronal Survival","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":214,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging","keywords":"CREB; Mitochondrion; Mitochondrial DNA; Biology; DNAJA3; Cyclic AMP Response Element-Binding Protein; Cell biology; Protein subunit; Transcription factor; Gene expression; mitochondrial fusion; Molecular biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002739594,0.0002928812,0.0003890165,0.00005789856,0.0001714851,0.00009484318,0.0004432184,0.0001768256,0.0003467086],"category_scores_gemma":[0.004722443,0.0002095046,0.0001827844,0.0001345717,0.0002730607,0.0001394978,0.000207394,0.000453362,0.00001461541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000536651,"about_ca_system_score_gemma":0.0001049024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":3.818056e-7,"about_ca_topic_score_gemma":2.975344e-7,"domain_scores_codex":[0.997177,0.0006127715,0.0007059319,0.0005198687,0.0005753391,0.0004091068],"domain_scores_gemma":[0.9981208,0.0006630323,0.0005246294,0.0002157986,0.00009034225,0.0003853271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002960196,0.0001922703,0.0005758963,0.0000101627,0.000006190877,0.00003640835,0.0000221649,0.00003074773,0.9956853,0.000002880635,0.000303282,0.0001745171],"study_design_scores_gemma":[0.001599143,0.000281556,0.0008253001,0.00003336642,0.00001458988,0.0001145995,0.00002396227,0.000009732277,0.994791,0.00007118243,0.002015493,0.0002200335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984274,0.0001158451,0.00009821162,0.0005732969,0.0004244144,0.0002097001,0.00005752435,0.00002662976,0.00006696874],"genre_scores_gemma":[0.9933962,0.00008365766,0.003842825,0.0001554027,0.002210549,0.00001610775,0.000006092719,0.00002011101,0.0002690943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005031249,"threshold_uncertainty_score":0.8543348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03991236005218361,"score_gpt":0.282005003313793,"score_spread":0.2420926432616094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}