{"id":"W2167116134","doi":"10.1371/journal.pbio.1001199","title":"Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer","year":2011,"lang":"en","type":"article","venue":"PLoS Biology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute","funders":"National Institute for Health and Care Research; National Cancer Institute; Cancer Research UK; European Molecular Biology Laboratory; University of Pennsylvania; University of Alberta; Brigham and Women's Hospital","keywords":"Biology; Carcinogenesis; Breast cancer; Cell polarity; Cancer research; Penetrance; Progenitor cell; Stem cell; Cell biology; Genetics; Cell; Cancer; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000248991,0.0002231624,0.0002106311,0.0003414265,0.0001406918,0.0002919176,0.0001632909,0.0002281786,0.001174175],"category_scores_gemma":[0.000437041,0.00009537289,0.0002219323,0.0002073142,0.0001791265,0.0001380303,0.0002157379,0.0002422666,0.0001440684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002263051,"about_ca_system_score_gemma":0.0001298007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001825806,"about_ca_topic_score_gemma":0.001252371,"domain_scores_codex":[0.9998374,0.00006253731,0.000006921625,0.00003905268,0.00002462052,0.00002943424],"domain_scores_gemma":[0.9997939,0.00003961506,0.000103058,0.00001803418,0.00001336122,0.00003196563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00248624,0.0001209301,0.7470728,0.00007938528,0.0003771365,0.001080877,0.0001425436,0.0006732406,0.2159051,0.0005731176,0.0004887803,0.03099995],"study_design_scores_gemma":[0.00001354833,0.0001475189,0.9842997,0.000009335807,0.0001204906,0.001163565,0.00008600816,0.001053634,0.01195166,0.0003687079,0.0007784041,0.000007465099],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997279,0.001199701,0.0004772629,0.0001356298,0.000004004082,0.000003886886,0.0001913464,0.00003036848,0.0006788499],"genre_scores_gemma":[0.9991365,0.0002829063,0.0001672875,0.00002325403,0.00000328342,0.000002570034,0.00006922075,0.000004392013,0.0003104884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001825806,"threshold_uncertainty_score":0.003928006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01181044125348235,"score_gpt":0.2681747036396555,"score_spread":0.2563642623861731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}