{"id":"W2167144649","doi":"10.1111/j.1399-3011.2004.00147.x","title":"Single‐point mutations at the surface of MB‐1Trp lead to important changes in its conformational properties","year":2004,"lang":"en","type":"article","venue":"Journal of Peptide Research","topic":"Biopolymer Synthesis and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"Circular dichroism; Point mutation; Mutant; Denaturation (fissile materials); Melting temperature; Mutation; Chemistry; Amino acid; Protein structure; Biophysics; Mutagenesis; Protein tertiary structure; Biochemistry; Protein folding; Melting point; Crystallography; Biology; Materials science; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001031061,0.00006187787,0.0001092056,0.00008960536,0.00009891666,0.0000218292,0.0002237079,0.00005182813,0.00003207374],"category_scores_gemma":[0.0002318723,0.00003974089,0.00005526638,0.0001887513,0.000133126,0.00000801145,0.0001003904,0.0001447728,0.00001047659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006183378,"about_ca_system_score_gemma":0.0002245714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004423838,"about_ca_topic_score_gemma":0.0006768435,"domain_scores_codex":[0.9989308,0.00006636824,0.0003638178,0.00008782273,0.0003700763,0.00018114],"domain_scores_gemma":[0.9991501,0.00003725932,0.0001464374,0.0001529226,0.0004492079,0.00006407905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006475967,0.00009193731,0.0002924848,0.00001496907,0.00001980247,0.000001587787,0.0003772381,0.000438648,0.9972152,0.0002616016,0.0006986758,0.0005230861],"study_design_scores_gemma":[0.000224037,0.000287642,0.001314939,0.00006345362,0.000003938267,0.00003926715,0.00103737,0.0000140584,0.9893289,0.00008155731,0.007555636,0.00004920783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857093,0.001666493,0.00006961843,0.01170434,0.00002003592,0.0001829535,0.00001771649,9.521939e-7,0.0006285796],"genre_scores_gemma":[0.9986359,0.0002732433,0.0003332574,0.00007396198,0.00008317817,0.00001194617,0.000005321605,0.000006572108,0.0005765912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01292662,"threshold_uncertainty_score":0.1620586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08040188241017407,"score_gpt":0.3436056706629121,"score_spread":0.263203788252738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}