{"id":"W2167147506","doi":"10.1128/jvi.79.10.6377-6391.2005","title":"The Nef-Mediated AIDS-Like Disease of CD4C/Human Immunodeficiency Virus Transgenic Mice Is Associated with Increased Fas/FasL Expression on T Cells and T-Cell Death but Is Not Prevented in Fas-, FasL-, Tumor Necrosis Factor Receptor 1-, or Interleukin-1β-Converting Enzyme-Deficient or Bcl2-Expressing Transgenic Mice","year":2005,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Toronto; Ontario Institute for Cancer Research; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Heart, Lung, and Blood Institute; National Institute for Health and Care Research","keywords":"Biology; Fas ligand; Transgene; Virology; Apoptosis; Genetically modified mouse; Human immunodeficiency virus (HIV); Programmed cell death; Disease; Virus; Immunodeficiency; Lentivirus; Immunology; Cancer research; Viral disease; Immune system; Gene; Genetics; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001161579,0.0006278023,0.0002815255,0.0005682191,0.0001532476,0.0002783447,0.000175267,0.0004885396,0.001480285],"category_scores_gemma":[0.0001047347,0.000186276,0.0002108684,0.0001581929,0.0002803601,0.0002287301,0.0001703696,0.0008441741,0.0005814809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002120068,"about_ca_system_score_gemma":0.0001254815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002692624,"about_ca_topic_score_gemma":0.0004387757,"domain_scores_codex":[0.9998449,0.00002157306,0.00001822632,0.00004317789,0.00004006516,0.00003206732],"domain_scores_gemma":[0.9997877,0.0000273718,0.00007986265,0.00002323754,0.00001812649,0.00006372247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008851264,0.00002506985,0.000243974,0.00002506287,0.000003938623,0.0001051544,0.00001355855,0.00001720942,0.9987048,0.00005698191,0.00002107101,0.0006947676],"study_design_scores_gemma":[0.00004893166,0.0006625744,0.00954574,0.00001293875,0.0000234791,0.003018863,0.00003845917,0.0005232447,0.9838462,0.0001247026,0.002147407,0.000007546758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947379,0.001360978,0.001979259,0.00005004919,0.00001919146,0.00003301815,0.0004564614,0.0001233996,0.001239805],"genre_scores_gemma":[0.9909456,0.001011897,0.003172355,0.00005214605,0.0000180509,0.00007477509,0.0009354436,0.00003610233,0.003753577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001480285,"threshold_uncertainty_score":0.004952013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817193248170057,"score_gpt":0.2567457684551206,"score_spread":0.2385738359734201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}