{"id":"W2167156151","doi":"10.1093/molbev/msu140","title":"Origin of Robustness in Generating Drug-Resistant Malaria Parasites","year":2014,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Malaria Research and Control","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Science, Mahidol University; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Royal Golden Jubilee (RGJ) Ph.D. Programme; Hearst Foundations; National Science and Technology Development Agency; Grand Challenges Canada; Howard Hughes Medical Institute; Mahidol University; Thailand Research Fund","keywords":"Biology; Dihydrofolate reductase; Nonsynonymous substitution; Robustness (evolution); Pyrimethamine; Genetics; Drug resistance; GTP cyclohydrolase I; Plasmodium falciparum; Gene; Computational biology; Malaria; Enzyme; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000382241,0.00006456762,0.0001741496,0.00009242329,0.00003057694,0.000003226664,0.0000324657,0.00008762194,0.00001695869],"category_scores_gemma":[0.0001968652,0.00005314568,0.00002798159,0.00009276678,0.00007690662,0.00001595778,0.00001894883,0.0001044075,0.00000160029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000209536,"about_ca_system_score_gemma":0.00003961434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000176408,"about_ca_topic_score_gemma":0.0000747528,"domain_scores_codex":[0.9993019,0.0001714783,0.0001471389,0.0001516988,0.0000558807,0.0001719676],"domain_scores_gemma":[0.9997228,0.00003379605,0.00003542925,0.0001111752,0.00004654618,0.00005029097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003166586,0.00004504469,0.1149925,0.00005021041,0.00002458298,0.0000104651,0.0000162133,0.0002300838,0.8052854,0.07752325,0.0000218844,0.001483691],"study_design_scores_gemma":[0.004579206,0.0007180048,0.8032135,0.0001214106,0.00006858168,0.00003238819,0.00005996998,0.1644943,0.02217394,0.00398187,0.000349584,0.0002071922],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9175236,0.0008880011,0.08021703,0.0009281451,0.00002740988,0.000142389,0.000001870204,0.00000838941,0.0002631287],"genre_scores_gemma":[0.9976106,0.00001265951,0.00218003,0.00006348681,0.00003664144,0.00001489187,0.0000211664,0.000004215708,0.00005636237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7831115,"threshold_uncertainty_score":0.2167218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007895913882207463,"score_gpt":0.2817103379364375,"score_spread":0.27381442405423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}