{"id":"W2167156151","doi":"10.1093/molbev/msu140","title":"Origin of Robustness in Generating Drug-Resistant Malaria Parasites","year":2014,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Malaria Research and Control","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Science, Mahidol University; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Royal Golden Jubilee (RGJ) Ph.D. Programme; Hearst Foundations; National Science and Technology Development Agency; Grand Challenges Canada; Howard Hughes Medical Institute; Mahidol University; Thailand Research Fund","keywords":"Biology; Dihydrofolate reductase; Nonsynonymous substitution; Robustness (evolution); Pyrimethamine; Genetics; Drug resistance; GTP cyclohydrolase I; Plasmodium falciparum; Gene; Computational biology; Malaria; Enzyme; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002844135,0.0002642819,0.0002762385,0.0003091599,0.0002511844,0.0004471381,0.0002343243,0.0003685743,0.0009502803],"category_scores_gemma":[0.0007098896,0.0001611194,0.0002703124,0.0001978279,0.0003988128,0.0003406219,0.0006788368,0.0005817267,0.0001563798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005032118,"about_ca_system_score_gemma":0.0001851768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003979937,"about_ca_topic_score_gemma":0.0005428039,"domain_scores_codex":[0.99978,0.00006942246,0.00001232577,0.0000402385,0.00006487625,0.00003318013],"domain_scores_gemma":[0.9997709,0.00005800788,0.00008340406,0.00003798576,0.00001807783,0.00003157033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001007719,0.0000200603,0.003542605,0.00004807711,0.00002904215,0.0003010608,0.000076449,0.003984418,0.9746714,0.007717832,0.0000868004,0.009421461],"study_design_scores_gemma":[0.00006718819,0.001013949,0.05871484,0.00004129574,0.0001518091,0.004909417,0.0002554876,0.1097937,0.7933288,0.01474905,0.01685146,0.0001229873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720407,0.0003791765,0.0241364,0.0002258967,0.00001214809,0.0000323349,0.0001186744,0.000155335,0.002899289],"genre_scores_gemma":[0.9910526,0.0002016192,0.007964651,0.00003717588,0.000004972977,0.00001814206,0.00007899309,0.00002601539,0.0006158906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009502803,"threshold_uncertainty_score":0.003651083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007895913882207463,"score_gpt":0.2817103379364375,"score_spread":0.27381442405423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}