{"id":"W2167188607","doi":"10.1093/hmg/ddi174","title":"HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells","year":2005,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"","keywords":"Biology; Chaperone (clinical); Heat shock protein; Hsp27; Cell biology; Protein aggregation; HSPA4; Transfection; Hsp70; Proteasome; In vivo; Biochemistry; In vitro; HSF1; Hsp90; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002845041,0.0005849568,0.000559792,0.0002324609,0.0003234652,0.0003587513,0.0003134096,0.0003526555,0.001420916],"category_scores_gemma":[0.0001234389,0.0002238176,0.000357375,0.0003122039,0.0001699733,0.0002296705,0.0003591433,0.0007424729,0.001145466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003222561,"about_ca_system_score_gemma":0.0001877416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001915744,"about_ca_topic_score_gemma":0.001899356,"domain_scores_codex":[0.9996566,0.00008400884,0.00005336536,0.00008884024,0.00008462059,0.00003265029],"domain_scores_gemma":[0.999858,0.00002956482,0.00002125143,0.00004323528,0.0000244359,0.00002348568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008615549,0.00004195093,0.0001430431,0.00006019529,0.000009840969,0.00006229092,0.00002468869,0.0000438503,0.9985363,0.00002972277,0.00009696677,0.000864837],"study_design_scores_gemma":[0.00001755469,0.0002977291,0.002556454,0.000008254281,0.00002847739,0.000296908,0.0000256689,0.0008626744,0.9920535,0.00002941094,0.003819104,0.000004344059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651992,0.01020727,0.01470498,0.0003764754,0.0002184918,0.00008369009,0.003684878,0.0004741362,0.005050979],"genre_scores_gemma":[0.9673594,0.005076625,0.009929129,0.0001240116,0.00005536766,0.000199672,0.006684018,0.0001109862,0.01046074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001915744,"threshold_uncertainty_score":0.004753411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956346265223498,"score_gpt":0.2738569277847595,"score_spread":0.2542934651325245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}