{"id":"W2167190147","doi":"10.1093/hmg/ddr203","title":"Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans : rescue by the DAF-16 and HSF-1 pathways","year":2011,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"RIKEN Brain Science Institute; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Fundação para a Ciência e a Tecnologia; National Ataxia Foundation; National Institutes of Health; Universidade do Minho; National Institute on Aging; University of Alberta; National Center for Research Resources; RIKEN; Karolinska Institutet; University of Tokyo; Northwestern University","keywords":"Biology; Caenorhabditis elegans; Proteotoxicity; Cell biology; Mutant; Neuron; Sensory neuron; HSF1; Heat shock factor; Phenotype; Downregulation and upregulation; Genetics; Heat shock protein; Neuroscience; Protein aggregation; Gene; Hsp70; Sensory system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002975568,0.00030432,0.0002592073,0.00006283836,0.0001237012,0.00003165707,0.0005264333,0.000212761,0.00003076319],"category_scores_gemma":[0.00002659942,0.00027233,0.00009855253,0.000114628,0.0003841537,0.000003685199,0.0003042626,0.0002310414,0.00000353628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000017385,"about_ca_system_score_gemma":0.00004915802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001269901,"about_ca_topic_score_gemma":0.000227324,"domain_scores_codex":[0.9981003,0.0001967521,0.0004544914,0.0005801074,0.0002526773,0.0004156765],"domain_scores_gemma":[0.9987094,0.00000739689,0.0001402177,0.0009377336,0.00009109582,0.0001140919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003024762,0.0001486086,0.002538132,0.00003008247,0.00002915736,0.00001537334,0.0009058155,0.00005462007,0.9948793,0.0003994991,0.0003372112,0.0006319249],"study_design_scores_gemma":[0.0006363351,0.0005614406,0.02382955,0.00001696227,0.00002743038,0.00002710191,0.0001709937,0.00005774306,0.9697374,0.001064972,0.003523015,0.0003471293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881915,0.004152062,0.006158073,0.00003681409,0.00007109173,0.0006259002,0.00004426791,0.00001246142,0.0007078252],"genre_scores_gemma":[0.9975371,0.0008972342,0.00105086,0.0002346539,0.00005667464,0.00003558004,0.0000499162,0.00006489724,0.00007307369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.025142,"threshold_uncertainty_score":0.9999729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02514621961256479,"score_gpt":0.2173501208103637,"score_spread":0.1922039011977989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}