{"id":"W2167226908","doi":"10.1038/sj.embor.7400279","title":"Oct4 is required for primordial germ cell survival","year":2004,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":565,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Biology; Embryonic stem cell; Germline; Cell biology; Stem cell; Inner cell mass; Germ cell; Genetics; Embryo; Lineage (genetic); Cellular differentiation; Null cell; Function (biology); Gene; Embryogenesis; Blastocyst","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001862439,0.0004062335,0.0002962298,0.0004039682,0.0004348651,0.0009358975,0.0004061805,0.0004676014,0.00262646],"category_scores_gemma":[0.0002962069,0.000512896,0.0003371869,0.0001960529,0.0004143967,0.0004994674,0.0004809306,0.001014743,0.001109471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00080064,"about_ca_system_score_gemma":0.0006240357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002367335,"about_ca_topic_score_gemma":0.004605286,"domain_scores_codex":[0.9997764,0.00002328169,0.00001986908,0.00003596628,0.00006976621,0.00007471749],"domain_scores_gemma":[0.9995555,0.00006267526,0.0001127611,0.00005541092,0.00005687663,0.0001568249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001618719,0.000007986708,0.000486021,0.00002299916,0.000008152126,0.0001171719,0.000005278932,0.0000723648,0.9979042,0.0002040574,0.0000822717,0.0009274592],"study_design_scores_gemma":[0.00002668729,0.00004239585,0.01374004,0.000005891918,0.00002595559,0.000585938,0.00004412517,0.001127486,0.9800099,0.000230414,0.00415187,0.000009513587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842636,0.00250098,0.005626325,0.0004776154,0.0001244437,0.00001950795,0.001077611,0.0003682639,0.00554158],"genre_scores_gemma":[0.9864987,0.0006991324,0.002221429,0.0001605917,0.00002149868,0.00001257579,0.001676803,0.0001825868,0.008526746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00262646,"threshold_uncertainty_score":0.008786321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01884365741436072,"score_gpt":0.2866117462480047,"score_spread":0.2677680888336439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}