{"id":"W2167246165","doi":"10.1128/aac.05857-11","title":"Correlation of the Virological Response to Short-Term Maraviroc Monotherapy with Standard and Deep-Sequencing-Based Genotypic Tropism Prediction Methods","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; University of British Columbia","funders":"","keywords":"Maraviroc; Tropism; CCR5 receptor antagonist; Genotype; Tissue tropism; Biology; Gold standard (test); Virology; Viral load; Internal medicine; Algorithm; Medicine; Human immunodeficiency virus (HIV); Immunology; Genetics; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003368988,0.0004599158,0.0008219634,0.0006808778,0.0001733996,0.0007883519,0.0003075381,0.0005562723,0.0005664612],"category_scores_gemma":[0.007723341,0.0002273568,0.0003987797,0.0005475265,0.0003247308,0.0004549087,0.0005623199,0.0008443375,0.000215461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004151899,"about_ca_system_score_gemma":0.0002416525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006468524,"about_ca_topic_score_gemma":0.0009651369,"domain_scores_codex":[0.9973485,0.0008037693,0.0003640662,0.000514531,0.0006901657,0.0002788939],"domain_scores_gemma":[0.9918615,0.004124971,0.001666673,0.0004908857,0.001217893,0.0006381049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004091659,0.0001538361,0.9482425,0.0001544831,0.0004383503,0.0001849066,0.0002245544,0.003746762,0.01259195,0.00008767633,0.0002992675,0.02978408],"study_design_scores_gemma":[0.00008398081,0.002358163,0.9608517,0.00005261945,0.0002442093,0.001065004,0.0002753341,0.02464958,0.00882702,0.0002665138,0.001269146,0.00005665694],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947519,0.001570136,0.002231854,0.00004784272,0.00001916597,0.00004001929,0.0005690428,0.00002886677,0.0007411946],"genre_scores_gemma":[0.9974837,0.0001237946,0.001386792,0.00006765506,0.00001338905,0.00003004595,0.0007444932,0.000009028703,0.0001410779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003368988,"threshold_uncertainty_score":0.01781714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.024830213832422,"score_gpt":0.2794406153524795,"score_spread":0.2546104015200575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}