{"id":"W2167247034","doi":"10.1093/intimm/dxl009","title":"Activation of thymic T cells by MHC alloantigen requires syngeneic, activated CD4+ T cells and B cells as APC","year":2006,"lang":"en","type":"article","venue":"International Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Saskatchewan","funders":"","keywords":"CD40; Antigen-presenting cell; Cytotoxic T cell; T cell; Immunology; Cell biology; CD28; IL-2 receptor; Interleukin 21; CD8; Antigen; Biology; Chemistry; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638366,0.0003795844,0.0001959938,0.000142432,0.0001755116,0.0004256634,0.000180879,0.0002797033,0.001275496],"category_scores_gemma":[0.0001967414,0.0001400585,0.0001935772,0.0001256211,0.0001769443,0.0002371043,0.0002560289,0.000406681,0.0006006357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001613454,"about_ca_system_score_gemma":0.0001935794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001159699,"about_ca_topic_score_gemma":0.0003021066,"domain_scores_codex":[0.9997805,0.00006253399,0.00002409328,0.00002709133,0.00005684116,0.00004902566],"domain_scores_gemma":[0.9998167,0.00006732215,0.00003931479,0.00002789134,0.00001473768,0.00003401776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008257108,0.00003957367,0.0004113578,0.00005423609,0.000002396873,0.0001042092,0.00001047305,0.0001583567,0.9977707,0.0001483723,0.00001116871,0.001206751],"study_design_scores_gemma":[0.00003787008,0.000680113,0.004221923,0.00001372542,0.00002232354,0.0007650009,0.00004671445,0.0007629386,0.9900491,0.0002353624,0.003159732,0.000005228794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913366,0.002251102,0.003525922,0.00003707329,0.0000189718,0.00004140387,0.0001144039,0.0000324168,0.002642116],"genre_scores_gemma":[0.9927942,0.001458604,0.004112769,0.00003731964,0.00002656157,0.00004395626,0.0004311125,0.00001510911,0.001080463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001275496,"threshold_uncertainty_score":0.004266977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005460354349132683,"score_gpt":0.225453999978351,"score_spread":0.2199936456292183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}