{"id":"W2167262304","doi":"10.1042/bj20050272","title":"Effects of nitric oxide donors on cybrids harbouring the mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) A3243G mitochondrial DNA mutation","year":2005,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada; National Research Council Canada; Ottawa Hospital; Institute for Biological Sciences","funders":"","keywords":"Lactic acidosis; MELAS syndrome; Mitochondrial myopathy; Mitochondrial DNA; Nitric oxide; Mitochondrion; Reactive oxygen species; Biology; Mutation; Cytochrome c oxidase; Acidosis; Programmed cell death; Oxidative stress; Molecular biology; Internal medicine; Biochemistry; Endocrinology; Apoptosis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836744,0.000312109,0.0005383111,0.00015372,0.0001761474,0.0002138335,0.0002194341,0.0002649023,0.0008396528],"category_scores_gemma":[0.0002001251,0.0001020574,0.0001946343,0.0001043085,0.0001675065,0.0001503784,0.000176169,0.0003058057,0.0001569988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001762369,"about_ca_system_score_gemma":0.0001591084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000876377,"about_ca_topic_score_gemma":0.001434612,"domain_scores_codex":[0.9998472,0.00005272754,0.0000214447,0.00003066052,0.00002941695,0.00001850883],"domain_scores_gemma":[0.9998409,0.00005086893,0.00003033366,0.00001735883,0.00002100514,0.00003968771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009452284,0.0001079715,0.0003401445,0.00006250523,0.00002354871,0.0001890633,0.00006822914,0.0001254989,0.9959715,0.0001135753,0.00005016059,0.002002596],"study_design_scores_gemma":[0.0001451576,0.004931789,0.007509474,0.00001944136,0.00008410664,0.0004445263,0.0001221736,0.001700824,0.9832014,0.0000660832,0.001762337,0.0000125743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982778,0.0007366164,0.0002528533,0.00004073539,0.00002623006,0.00002119565,0.0001184142,0.0000177877,0.0005083783],"genre_scores_gemma":[0.997642,0.0005749377,0.0005260737,0.00003181173,0.000008148834,0.00002762384,0.0002687403,0.000007246741,0.0009133589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000876377,"threshold_uncertainty_score":0.002808928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00529343813405169,"score_gpt":0.2189622330578026,"score_spread":0.2136687949237509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}