{"id":"W2167262304","doi":"10.1042/bj20050272","title":"Effects of nitric oxide donors on cybrids harbouring the mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) A3243G mitochondrial DNA mutation","year":2005,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada; National Research Council Canada; Ottawa Hospital; Institute for Biological Sciences","funders":"","keywords":"Lactic acidosis; MELAS syndrome; Mitochondrial myopathy; Mitochondrial DNA; Nitric oxide; Mitochondrion; Reactive oxygen species; Biology; Mutation; Cytochrome c oxidase; Acidosis; Programmed cell death; Oxidative stress; Molecular biology; Internal medicine; Biochemistry; Endocrinology; Apoptosis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002354513,0.0003410365,0.0003471372,0.0001546496,0.0002471632,0.00008969461,0.00034688,0.0003611322,0.00003619677],"category_scores_gemma":[0.0007790221,0.00026033,0.0002742321,0.0001596953,0.0002466427,0.00002338025,0.0001298121,0.0005236228,0.00001930141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005269707,"about_ca_system_score_gemma":0.0001044378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001085276,"about_ca_topic_score_gemma":0.000004894004,"domain_scores_codex":[0.9977854,0.0003121342,0.0005817529,0.0005006029,0.0003780034,0.0004420728],"domain_scores_gemma":[0.9986825,0.0002172031,0.0003697055,0.000326532,0.0001459801,0.0002580796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001047039,0.0001517157,0.0003420802,0.00003103478,0.00008317653,0.00002214984,0.00007378589,0.00003339765,0.9911183,0.00002761284,0.002699424,0.004370345],"study_design_scores_gemma":[0.002569776,0.0005386079,0.001416835,0.00005926651,0.0001307181,0.0005483134,0.00006740225,0.00004027089,0.9879748,0.00008536276,0.006279901,0.0002886988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992585,0.002106914,0.002916574,0.0003502614,0.001541491,0.0003413014,0.00001871623,0.00001794763,0.0001217724],"genre_scores_gemma":[0.9899795,0.0009950618,0.003687591,0.0005184714,0.004456287,0.0000374851,0.00002825476,0.00004103936,0.0002563013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004081646,"threshold_uncertainty_score":0.9999849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00529343813405169,"score_gpt":0.2189622330578026,"score_spread":0.2136687949237509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}