{"id":"W2167293188","doi":"10.1021/ja407486z","title":"Bioanalysis for Biocatalysis: Multiplexed Capillary Electrophoresis–Mass Spectrometry Assay for Aminotransferase Substrate Discovery and Specificity Profiling","year":2013,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Chemistry; Bioanalysis; Capillary electrophoresis; Chromatography; Mass spectrometry; Drug discovery; Substrate (aquarium); Biocatalysis; Biochemistry; Catalysis; Reaction mechanism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001714787,0.002306071,0.00103363,0.001892926,0.0006084003,0.0013673,0.001840482,0.00206052,0.001205661],"category_scores_gemma":[0.001935991,0.0008337342,0.0007236094,0.0008704778,0.0007676219,0.001095497,0.0009678344,0.001659933,0.001431142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009139011,"about_ca_system_score_gemma":0.001121631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006702177,"about_ca_topic_score_gemma":0.001940624,"domain_scores_codex":[0.9970306,0.0005198602,0.0001989788,0.0007308416,0.001352863,0.0001668833],"domain_scores_gemma":[0.9983499,0.0005258995,0.0002804142,0.000217486,0.000481093,0.0001452324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006906215,0.00006492784,0.0004077328,0.00009686351,0.00002982461,0.0000454435,0.00002659769,0.0001451634,0.9867024,0.0003598916,0.0001983676,0.01185376],"study_design_scores_gemma":[0.000007770255,0.0001184983,0.0007159755,0.000009856228,0.0000212175,0.0002336349,0.00001063622,0.005163398,0.9913201,0.0001668297,0.002205731,0.00002628257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1227516,0.006084836,0.8622364,0.0004178389,0.0005397659,0.0007742253,0.0009473095,0.003717039,0.002530872],"genre_scores_gemma":[0.2131643,0.003845615,0.7763535,0.0005614111,0.0001430863,0.001240051,0.001277359,0.0001939591,0.003220693],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002306071,"threshold_uncertainty_score":0.009068727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007902109990063836,"score_gpt":0.2331935301598971,"score_spread":0.2252914201698333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}