{"id":"W2167305078","doi":"10.1111/j.1365-2133.2012.11168.x","title":"Efficacy and safety of tofacitinib, an oral Janus kinase inhibitor, in the treatment of psoriasis: a Phase 2b randomized placebo-controlled dose-ranging study","year":2012,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":336,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Probity Medical Research","funders":"Pfizer","keywords":"Tofacitinib; Janus kinase inhibitor; Medicine; Placebo; Psoriasis; Adverse effect; Psoriasis Area and Severity Index; Dose-ranging study; Internal medicine; Gastroenterology; Randomized controlled trial; Clinical endpoint; Dermatology; Double blind; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004866872,0.001687004,0.003012461,0.000684546,0.0004803725,0.00132625,0.001087343,0.002011358,0.006247609],"category_scores_gemma":[0.00291175,0.0008689719,0.002117662,0.0006783392,0.001087242,0.001153435,0.0004531851,0.003226464,0.001141647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007939254,"about_ca_system_score_gemma":0.001168392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003589155,"about_ca_topic_score_gemma":0.000772342,"domain_scores_codex":[0.9977989,0.001302892,0.0001655111,0.0002932467,0.0002639516,0.0001755192],"domain_scores_gemma":[0.9979306,0.0005831495,0.0006850194,0.0001729054,0.0001550736,0.0004731809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9482352,0.02112079,0.0009948835,0.00053548,0.0008120053,0.00003956044,0.00005235407,0.0003014488,0.008707815,0.00003725999,0.0004932551,0.01867003],"study_design_scores_gemma":[0.8588905,0.1361943,0.00303676,0.00002064965,0.0003922561,0.00005466613,0.00001238168,0.0002399227,0.0007117433,0.00005767515,0.0003747531,0.00001454822],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863224,0.004802087,0.0008061509,0.0003968292,0.0002287333,0.004859712,0.001268189,0.0001135916,0.001202311],"genre_scores_gemma":[0.98493,0.003099181,0.002176153,0.0009304896,0.0005487115,0.005384293,0.001351019,0.00003811429,0.001541968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006247609,"threshold_uncertainty_score":0.02573878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01880262927208139,"score_gpt":0.2817837546567371,"score_spread":0.2629811253846557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}