{"id":"W2167310267","doi":"10.1093/toxsci/kfg054","title":"Synergistic Role of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Cholesterol 7alpha-Hydroxylase in the Pathogenesis of Manganese-Bilirubin-Induced Cholestasis in Rats","year":2003,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Liver Foundation","keywords":"Cholestasis; Cholesterol; Internal medicine; Endocrinology; Reductase; Cholesterol 7 alpha-hydroxylase; Chemistry; Phospholipid; Sterol O-acyltransferase; Reverse cholesterol transport; Bile acid; HMG-CoA reductase; Biochemistry; Bilirubin; Enzyme; Biology; Medicine; Lipoprotein; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001889165,0.0001868279,0.0005110241,0.0002076364,0.00007841868,0.00001441263,0.0002733091,0.0001418419,0.00007355986],"category_scores_gemma":[0.0003207822,0.0001060567,0.0000813045,0.001052833,0.0006776581,0.00008081871,0.00002420371,0.0001928498,0.000001581563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003060641,"about_ca_system_score_gemma":0.000107278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009768489,"about_ca_topic_score_gemma":0.0002378531,"domain_scores_codex":[0.9979357,0.0002440353,0.0005255641,0.0004304481,0.0004887033,0.0003756104],"domain_scores_gemma":[0.9991998,0.000262995,0.0001482037,0.0002381041,0.0000335132,0.0001173517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001047776,0.0007959213,0.01781526,0.00006825363,0.00000713231,0.0001355356,0.0007595476,0.00005427273,0.9760729,0.002455176,0.000004065288,0.001727181],"study_design_scores_gemma":[0.002003927,0.001804995,0.3405219,0.0002444977,0.000088852,0.00006674987,0.004987766,0.0003062061,0.644901,0.004653167,0.0001334206,0.0002875124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974081,0.0007413716,0.00001267165,0.0004696492,0.00004974144,0.0005280516,0.00001341263,0.0000116457,0.0007653474],"genre_scores_gemma":[0.9991583,0.00009863193,0.0004764121,0.0001932184,0.00001111112,0.000039836,0.000002699631,0.000005387088,0.00001440391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3311719,"threshold_uncertainty_score":0.4324867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02895982736470616,"score_gpt":0.2849027233110341,"score_spread":0.255942895946328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}