{"id":"W2167310267","doi":"10.1093/toxsci/kfg054","title":"Synergistic Role of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Cholesterol 7alpha-Hydroxylase in the Pathogenesis of Manganese-Bilirubin-Induced Cholestasis in Rats","year":2003,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Liver Foundation","keywords":"Cholestasis; Cholesterol; Internal medicine; Endocrinology; Reductase; Cholesterol 7 alpha-hydroxylase; Chemistry; Phospholipid; Sterol O-acyltransferase; Reverse cholesterol transport; Bile acid; HMG-CoA reductase; Biochemistry; Bilirubin; Enzyme; Biology; Medicine; Lipoprotein; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003890253,0.001063325,0.001119755,0.0008415502,0.0002721611,0.0003281135,0.0004692779,0.0007649186,0.0008375471],"category_scores_gemma":[0.0002944882,0.0006561123,0.0005421865,0.0002644662,0.0008391757,0.0004686802,0.0005826648,0.001138656,0.0002502793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004191821,"about_ca_system_score_gemma":0.0005789514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009189502,"about_ca_topic_score_gemma":0.001445307,"domain_scores_codex":[0.9994357,0.0001403204,0.00005017825,0.00009653762,0.0001112118,0.0001661142],"domain_scores_gemma":[0.9993255,0.00005460259,0.0001709503,0.00007208531,0.00005093114,0.0003259026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007308185,0.000561817,0.002771938,0.00009961977,0.00007394343,0.0003868698,0.00005068229,0.00009943687,0.9846247,0.0001439304,0.00005630809,0.00382252],"study_design_scores_gemma":[0.0006238291,0.01760212,0.02286107,0.00002413122,0.0003898413,0.001275731,0.0001821278,0.002074477,0.9522011,0.000342399,0.002378151,0.00004500608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995115,0.002625459,0.001392397,0.0001904051,0.00003956225,0.00003989643,0.0000628437,0.0001229823,0.00041138],"genre_scores_gemma":[0.9947438,0.001532683,0.001722075,0.00009132904,0.00003471786,0.00006805217,0.0001532569,0.00001998438,0.001633913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001119755,"threshold_uncertainty_score":0.003041387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02895982736470616,"score_gpt":0.2849027233110341,"score_spread":0.255942895946328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}