{"id":"W2167325121","doi":"10.1128/jvi.01501-15","title":"Brain Invasion by Mouse Hepatitis Virus Depends on Impairment of Tight Junctions and Beta Interferon Production in Brain Microvascular Endothelial Cells","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Mouse hepatitis virus; Blood–brain barrier; Biology; Tropism; Occludin; Tight junction; Virology; Tissue tropism; Virus; Coronavirus; Interferon; Chemokine; Immunology; Viral replication; Central nervous system; Inflammation; Cell biology; Pathology; Neuroscience; Medicine; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001065927,0.0002839908,0.0001374364,0.0001781167,0.000113274,0.000210802,0.000110648,0.0001807142,0.0008058894],"category_scores_gemma":[0.00008525158,0.00009163571,0.000168413,0.0001015077,0.0001619292,0.0002052829,0.000151536,0.0004479064,0.0002947809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001586126,"about_ca_system_score_gemma":0.00009430169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003622699,"about_ca_topic_score_gemma":0.0003407623,"domain_scores_codex":[0.999881,0.0000209842,0.00001380584,0.00001905774,0.0000249003,0.00004018408],"domain_scores_gemma":[0.9998672,0.00001549752,0.0000567441,0.00001484347,0.00002090254,0.00002481635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001353504,0.00002057565,0.0006420499,0.0000295163,0.000003628354,0.00004666099,0.00001487059,0.000009200493,0.9984762,0.00002440134,0.00001052722,0.0005869824],"study_design_scores_gemma":[0.00001692576,0.0005766712,0.04841075,0.00001904131,0.00003340734,0.0006174454,0.00009277934,0.0004301659,0.948674,0.00006570745,0.00105796,0.00000524992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961615,0.001807044,0.0011552,0.00003132519,0.000009608807,0.00001175949,0.0001639653,0.00004568137,0.000613987],"genre_scores_gemma":[0.9968756,0.001033212,0.0009479478,0.00002256883,0.000005942714,0.00002922734,0.000296605,0.000006676828,0.0007821409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008058894,"threshold_uncertainty_score":0.002695978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0187984283676426,"score_gpt":0.2253954730939066,"score_spread":0.2065970447262639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}