{"id":"W2167325443","doi":"10.1016/j.bpj.2008.12.841","title":"Position Specificity of the Glycine Residues in IS6 of the L-type Cav1.2 Channel","year":2009,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Kinetics; Mutant; Chemistry; Glycine; Wild type; Residue (chemistry); Biophysics; Biochemistry; Amino acid; Stereochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005024464,0.0004190481,0.0004925167,0.0002362013,0.0004142346,0.0004591069,0.0004888552,0.0006962612,0.002760619],"category_scores_gemma":[0.0006463012,0.0001702734,0.0004736753,0.0002075183,0.0006408848,0.0004622622,0.0004162599,0.0007555255,0.001232751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003226044,"about_ca_system_score_gemma":0.0003447112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006989074,"about_ca_topic_score_gemma":0.00089355,"domain_scores_codex":[0.9996448,0.00009797844,0.00003973999,0.00007973587,0.00007680975,0.00006095304],"domain_scores_gemma":[0.999469,0.0001160708,0.0001317493,0.00004682218,0.00008758588,0.0001487968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001825233,0.0000622571,0.001748271,0.0001116988,0.00003946832,0.001021071,0.0001181324,0.0008857473,0.9879469,0.00152876,0.000328469,0.004383897],"study_design_scores_gemma":[0.0003328453,0.001003323,0.02295909,0.00007196845,0.0001422063,0.004065296,0.0002215028,0.006063597,0.9577276,0.001087615,0.006234411,0.00009049733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922017,0.0005889561,0.003904498,0.0002507964,0.0001258175,0.00002244831,0.0001862117,0.00005521416,0.002664396],"genre_scores_gemma":[0.9970453,0.0001649714,0.001549033,0.0001332998,0.00002485409,0.00000930137,0.0002186162,0.00002696378,0.0008275855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002760619,"threshold_uncertainty_score":0.009235203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109681852493498,"score_gpt":0.2544175082430941,"score_spread":0.2434493229937443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}