{"id":"W2167342132","doi":"10.4049/jimmunol.168.2.696","title":"α4 Integrin Signaling Activates Phosphatidylinositol 3-Kinase and Stimulates T Cell Adhesion to Intercellular Adhesion Molecule-1 to a Similar Extent As CD3, but Induces a Distinct Rearrangement of the Actin Cytoskeleton","year":2002,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"Cell biology; Integrin; Jurkat cells; Wortmannin; Integrin alpha M; Actin cytoskeleton; Cell adhesion; Biology; Integrin, beta 6; Filopodia; Lamellipodium; CD49c; Phosphatidylinositol; Signal transduction; Cytoskeleton; Molecular biology; Actin; T cell; Biochemistry; Cell; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006891695,0.0005174882,0.0002208932,0.0003305004,0.0002607529,0.000451676,0.0001363214,0.0003293407,0.002754862],"category_scores_gemma":[0.0001216321,0.0001639686,0.0005189941,0.0003849824,0.0001468628,0.000187699,0.0002600875,0.0007219084,0.00101591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005654683,"about_ca_system_score_gemma":0.0002664182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006819304,"about_ca_topic_score_gemma":0.0009806845,"domain_scores_codex":[0.9997763,0.00002762523,0.000009568855,0.00002691418,0.00005048753,0.0001090817],"domain_scores_gemma":[0.9999535,0.00000427689,0.00001577527,0.00000484631,0.000007395654,0.00001420722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002253751,0.00005884752,0.0003882059,0.00004853627,0.00001376837,0.0001216376,0.00001085758,0.00007833405,0.9950805,0.0001681332,0.00024669,0.003559171],"study_design_scores_gemma":[0.0001181504,0.0005168765,0.017015,0.00001636046,0.00006307909,0.0007071645,0.00008064861,0.001768096,0.9674846,0.0003329452,0.01188521,0.00001184157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985051,0.003929177,0.002547565,0.0003289078,0.0001404412,0.00006208439,0.0005128827,0.0001159948,0.007311869],"genre_scores_gemma":[0.9885118,0.002441335,0.001401409,0.0001680543,0.00005086694,0.00008198786,0.001012652,0.0000142242,0.006317654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002754862,"threshold_uncertainty_score":0.009215951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02427722662333332,"score_gpt":0.279748566485048,"score_spread":0.2554713398617147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}