{"id":"W2167357721","doi":"10.1016/j.cmet.2014.08.012","title":"Metabolic Inflexibility Impairs Insulin Secretion and Results In MODY-like Diabetes in Triple FoxO-Deficient Mice","year":2014,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"FOXO1; PDX1; Endocrinology; Internal medicine; Diabetes mellitus; Type 2 diabetes; Insulin; Biology; Secretion; Pancreas; Medicine; Cell biology; Islet; Signal transduction; Protein kinase B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001906099,0.0002663061,0.0007830594,0.0004565724,0.0000491807,0.00003044292,0.000091279,0.0001844413,0.00004214795],"category_scores_gemma":[0.001241534,0.0002308408,0.00009661058,0.0006663989,0.0001114075,0.000144352,0.00006754074,0.0003289091,0.0000434446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004662566,"about_ca_system_score_gemma":0.00007392006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000322384,"about_ca_topic_score_gemma":0.00004948862,"domain_scores_codex":[0.9976138,0.0002619709,0.000779098,0.0005793423,0.0002877256,0.0004780427],"domain_scores_gemma":[0.9987645,0.0002716689,0.0001682944,0.0004754753,0.00008300838,0.0002371256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003268883,0.003220078,0.3827354,0.001144262,0.0001296264,0.00002358512,0.006383194,0.0004870458,0.5395386,0.00548999,0.001969274,0.05561008],"study_design_scores_gemma":[0.01277811,0.000147364,0.8897297,0.00009521392,0.0001531066,0.000002573837,0.0002492535,0.01280819,0.0413825,0.001307852,0.04101234,0.0003338493],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826695,0.00737768,0.00005387744,0.0002700785,0.0004648161,0.0005803622,0.00002052774,0.00007317482,0.008490033],"genre_scores_gemma":[0.9973221,0.0004052171,0.0008163053,0.000767025,0.0001436849,0.00006520971,0.00006388579,0.00002485986,0.000391689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5069942,"threshold_uncertainty_score":0.9413415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211502354735994,"score_gpt":0.2367231065818702,"score_spread":0.2246080830345102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}