{"id":"W2167386605","doi":"10.1186/s40478-015-0202-6","title":"FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis","year":2015,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Core Research for Evolutional Science and Technology; RIKEN Brain Science Institute; RIKEN; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Amyotrophic lateral sclerosis; Phenotype; Frontotemporal lobar degeneration; Knockout mouse; Pathological; C9orf72; Biology; Pathogenesis; Downregulation and upregulation; Neuroscience; Pathology; Conditional gene knockout; Neurodegeneration; Medicine; Frontotemporal dementia; Gene; Genetics; Trinucleotide repeat expansion; Disease; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000498179,0.0003424687,0.0005312093,0.000137045,0.0005329368,0.00016872,0.0009688187,0.0002160345,0.0001391811],"category_scores_gemma":[0.0006962139,0.0002550701,0.0001232933,0.0003680732,0.001380002,0.0002945269,0.001780355,0.0008748068,0.00009535675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001039042,"about_ca_system_score_gemma":0.0001027283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000398872,"about_ca_topic_score_gemma":0.00004480908,"domain_scores_codex":[0.9967671,0.0009511619,0.000559867,0.0006037587,0.0005210803,0.0005970338],"domain_scores_gemma":[0.9964363,0.0003749433,0.0001619071,0.002209052,0.0002964346,0.0005213393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004624017,0.002642036,0.8175181,0.00003600925,0.00003708377,0.0008574649,0.003459659,0.000003923163,0.1655834,0.00132402,0.001186298,0.006889618],"study_design_scores_gemma":[0.0009983846,0.001045073,0.9944717,0.00005992912,0.000114072,0.0003327258,0.0002483457,0.0001392315,0.000112638,0.0005481825,0.001642575,0.0002871784],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898807,0.001096749,0.00001908966,0.005912364,0.00008395291,0.000375437,0.0001543245,0.0003147024,0.002162708],"genre_scores_gemma":[0.9931688,0.00194093,0.003399297,0.0007071946,0.00007798056,0.0001448781,0.0002249595,0.0000418249,0.0002940854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1769536,"threshold_uncertainty_score":0.9999902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2202472885396582,"score_gpt":0.3514495267576651,"score_spread":0.1312022382180069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}