{"id":"W2167393231","doi":"10.1074/jbc.m700917200","title":"Crystal Structure of Human Cytosolic 5′-Nucleotidase II","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"VINNOVA; Wellcome Trust","keywords":"Allosteric regulation; 5'-nucleotidase; Chemistry; Nucleotidase; Biochemistry; Cytosol; Active site; Protein subunit; Tetramer; Effector; Dephosphorylation; Thermotoga maritima; Nucleoside; Enzyme; Adenosine triphosphate; Stereochemistry; Phosphatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002297612,0.0001393723,0.0002416021,0.00002206581,0.00006798765,0.000005847915,0.0002572567,0.0002813039,0.0002349016],"category_scores_gemma":[0.0001276399,0.0000988894,0.0001904163,0.00007236381,0.0001272544,0.000003180539,0.0001150685,0.0002139728,2.859075e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001049388,"about_ca_system_score_gemma":0.00003724132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001711363,"about_ca_topic_score_gemma":3.227389e-7,"domain_scores_codex":[0.9990005,0.00001776771,0.0004935577,0.0001450857,0.0001398448,0.0002031727],"domain_scores_gemma":[0.9991353,0.00001843933,0.0004081997,0.0001508563,0.0001618078,0.0001254022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001379641,0.00007785078,0.003033184,0.00002059336,0.00004951571,0.00003249616,0.00001666488,0.0000157973,0.9951978,0.00001063863,0.001284201,0.0001232607],"study_design_scores_gemma":[0.0004940737,0.000559735,0.002110001,0.00002237732,0.00001624138,0.0003491193,0.00008263265,6.415953e-7,0.9920213,0.0001197984,0.0041016,0.0001225106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997372,0.001131857,0.0002360697,0.00003251139,0.00004515766,0.00001951511,0.00001345035,0.000003512582,0.001145907],"genre_scores_gemma":[0.9982827,0.00003986948,0.0004305614,0.00007364106,0.0009350368,1.213033e-7,0.00002706247,0.000008898767,0.0002021591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003176564,"threshold_uncertainty_score":0.4032592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382821850338219,"score_gpt":0.265449078380055,"score_spread":0.2516208598766729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}