{"id":"W2167393231","doi":"10.1074/jbc.m700917200","title":"Crystal Structure of Human Cytosolic 5′-Nucleotidase II","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"VINNOVA; Wellcome Trust","keywords":"Allosteric regulation; 5'-nucleotidase; Chemistry; Nucleotidase; Biochemistry; Cytosol; Active site; Protein subunit; Tetramer; Effector; Dephosphorylation; Thermotoga maritima; Nucleoside; Enzyme; Adenosine triphosphate; Stereochemistry; Phosphatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002855552,0.0006652111,0.0008523973,0.0001784888,0.0005265662,0.001028286,0.0009196342,0.0007538649,0.003484702],"category_scores_gemma":[0.0005212965,0.0004150308,0.0003061298,0.000593516,0.0002194761,0.0003868513,0.0002337727,0.001732984,0.001145525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001522049,"about_ca_system_score_gemma":0.001149329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008248135,"about_ca_topic_score_gemma":0.00785344,"domain_scores_codex":[0.9997888,0.00002662483,0.000008159862,0.00005925574,0.00007518719,0.0000419752],"domain_scores_gemma":[0.9997973,0.0000424378,0.00002771458,0.000007466531,0.00007337028,0.00005164741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004661797,0.001377728,0.01543173,0.002488992,0.0005897302,0.004267578,0.001415903,0.03366583,0.735107,0.01119076,0.1150731,0.07472978],"study_design_scores_gemma":[0.00389984,0.001931383,0.07373497,0.0006170902,0.0008620295,0.005261047,0.001989671,0.1915939,0.2885531,0.007578329,0.4236234,0.0003552811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8928579,0.02850323,0.01538906,0.003538031,0.001312894,0.0003260294,0.01769705,0.001268934,0.03910684],"genre_scores_gemma":[0.8715394,0.01055514,0.02356949,0.001426943,0.0002139502,0.0003279623,0.07040633,0.0002635575,0.0216972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008248135,"threshold_uncertainty_score":0.01640022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382821850338219,"score_gpt":0.265449078380055,"score_spread":0.2516208598766729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}