{"id":"W2167398354","doi":"10.1038/ng1640","title":"The synthetic genetic interaction spectrum of essential genes","year":2005,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":225,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Biology; Gene; Genetics; Mutant; Yeast; Computational biology; Genetic screen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000336399,0.0007121599,0.0003249364,0.0007313451,0.0002417836,0.0005095845,0.000408464,0.0003961509,0.003366982],"category_scores_gemma":[0.000746726,0.0002408582,0.0003095315,0.0002573878,0.0003547135,0.0005226533,0.0009183668,0.0009505217,0.0007030272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003539138,"about_ca_system_score_gemma":0.0001760873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001080402,"about_ca_topic_score_gemma":0.0001401403,"domain_scores_codex":[0.999608,0.00005885735,0.00001861811,0.00007617157,0.0001776101,0.00006084173],"domain_scores_gemma":[0.9992884,0.0003134909,0.00007518045,0.0001293686,0.00005222194,0.0001414805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001943749,0.0000242499,0.0002748667,0.00002779682,0.00001070401,0.000099456,0.000009618002,0.0004342489,0.9877864,0.004758876,0.0001567116,0.006222598],"study_design_scores_gemma":[0.00004713627,0.0003573084,0.005123471,0.00001490392,0.00005202296,0.002721009,0.00005016553,0.006778657,0.963971,0.0110485,0.009808877,0.00002692899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9200945,0.001702695,0.05104083,0.0005947509,0.00008884651,0.00003950568,0.0006449218,0.001299024,0.02449482],"genre_scores_gemma":[0.9897254,0.0007104762,0.006157869,0.0001913764,0.00003043373,0.00002968946,0.0006563973,0.0001804934,0.002317765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003366982,"threshold_uncertainty_score":0.01126367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00521645381536995,"score_gpt":0.2787987811037856,"score_spread":0.2735823272884156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}