{"id":"W2167398354","doi":"10.1038/ng1640","title":"The synthetic genetic interaction spectrum of essential genes","year":2005,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":225,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Biology; Gene; Genetics; Mutant; Yeast; Computational biology; Genetic screen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001748249,0.0001783335,0.0001294875,0.00005397828,0.0001562458,0.00004357645,0.0004758986,0.0003237375,0.00003760071],"category_scores_gemma":[0.00006997212,0.0001341091,0.0001319297,0.0001394681,0.0001807328,0.000002288352,0.0002136126,0.00032968,0.00003142723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001752832,"about_ca_system_score_gemma":0.0000960313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004282575,"about_ca_topic_score_gemma":0.0001283132,"domain_scores_codex":[0.998573,0.00008015676,0.0002940074,0.0003404894,0.0003512884,0.0003610255],"domain_scores_gemma":[0.9990169,0.00003280541,0.0001055386,0.0005926011,0.0001592321,0.00009296176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001685334,0.00009165877,0.002529102,0.00002347497,0.00009311414,0.000001983416,0.00003371822,0.002278156,0.9252923,0.00007533115,0.002195151,0.06721744],"study_design_scores_gemma":[0.0002205554,0.0001977824,0.003818525,0.000008259345,0.00002118338,0.00003236059,0.00003408728,0.0008576064,0.7990672,0.0001003864,0.195498,0.0001440067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9693232,0.02722237,0.0005168582,0.0007804221,0.0005634371,0.0002120766,0.00001786603,0.000009650857,0.00135409],"genre_scores_gemma":[0.9902751,0.005587433,0.001713975,0.0001007402,0.001225947,0.00001331417,0.00002137279,0.00003283096,0.001029249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1933029,"threshold_uncertainty_score":0.546881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00521645381536995,"score_gpt":0.2787987811037856,"score_spread":0.2735823272884156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}