{"id":"W2167409131","doi":"10.1186/bcr1670","title":"An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA)","year":2007,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Medical Research and Materiel Command; Deutsche Krebshilfe; National Cancer Institute; KWF Kankerbestrijding; Ministerstvo Školství, Mládeže a Tělovýchovy; National Breast Cancer Foundation; Huntsman Cancer Institute; Medical Research Council; Mayo Clinic; Cancer Care Ontario; Breast Cancer Research Foundation; University of Melbourne; Susan G. Komen; Helsingin ja Uudenmaan Sairaanhoitopiiri; National Health and Medical Research Council; Academy of Finland; Cancer Research UK; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Breast cancer; Medicine; Penetrance; Mutation; Cancer; Genetics; Oncology; Bioinformatics; Phenotype; Biology; Internal medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02566374,0.001229796,0.00108217,0.003469686,0.001901227,0.001990314,0.001839186,0.001879845,0.002480929],"category_scores_gemma":[0.01312383,0.0005139346,0.0008876176,0.003086508,0.001213762,0.0008170545,0.005948652,0.002987257,0.0006143264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001500871,"about_ca_system_score_gemma":0.01505587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01197352,"about_ca_topic_score_gemma":0.01420796,"domain_scores_codex":[0.9941279,0.003353523,0.0002198349,0.0007581725,0.000818072,0.0007224964],"domain_scores_gemma":[0.9781003,0.003744451,0.002845705,0.002401582,0.004080767,0.008827256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008375566,0.002535197,0.6276402,0.0008705336,0.002018018,0.0008660781,0.002189266,0.0008139714,0.02961589,0.009665086,0.07079103,0.2446191],"study_design_scores_gemma":[0.00442955,0.002160433,0.8421478,0.0003627801,0.001399372,0.001209761,0.001289938,0.001234489,0.006719153,0.00326865,0.135669,0.0001090578],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.720744,0.05378081,0.0696604,0.063455,0.005172697,0.01715093,0.0296673,0.001315139,0.03905369],"genre_scores_gemma":[0.6055804,0.01310109,0.2760069,0.0137878,0.002541995,0.02515054,0.03793608,0.0004666644,0.02542851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02566374,"threshold_uncertainty_score":0.1357244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04140015731477487,"score_gpt":0.4089990854202221,"score_spread":0.3675989281054473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}