{"id":"W2167415757","doi":"10.1111/j.1471-4159.2004.02810.x","title":"Opposite regulation of the mitochondrial apoptotic pathway by C2‐ceramide and PACAP through a MAP‐kinase‐dependent mechanism in cerebellar granule cells","year":2004,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"Institut National de la Santé et de la Recherche Médicale","keywords":"Ceramide; Lipid signaling; Cell biology; Apoptosis; MAPK/ERK pathway; Biology; Second messenger system; Mitochondrion; Adenylate kinase; Caspase; Signal transduction; Programmed cell death; Chemistry; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006429503,0.0001715105,0.0002698922,0.00002994644,0.00007697706,0.00003252651,0.0003447781,0.00008645672,0.0000118827],"category_scores_gemma":[0.0001100759,0.0001280384,0.0001247036,0.000141408,0.0001198876,0.0001578891,0.0001173498,0.000415711,0.000001954622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003849985,"about_ca_system_score_gemma":0.00006365374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001022747,"about_ca_topic_score_gemma":0.000001047877,"domain_scores_codex":[0.9985548,0.0001015101,0.0005028943,0.000278239,0.0003443997,0.0002182073],"domain_scores_gemma":[0.9990571,0.00008941965,0.0005170038,0.0002140044,0.00004933133,0.00007315644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000124712,0.0001322199,0.000008021401,0.00005876696,0.000002891134,0.00005372857,0.00009523913,0.0003221293,0.9988351,0.0002046012,0.0001166965,0.00004585345],"study_design_scores_gemma":[0.001123663,0.0002334057,0.0003732891,0.0001093395,0.00001356542,0.0002218615,0.00002776722,0.00001611935,0.9895017,0.007959814,0.0003119644,0.0001075696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988722,0.00005662348,0.00006593607,0.0003614006,0.0003584681,0.0001188494,0.00001805383,0.000005990138,0.0001424688],"genre_scores_gemma":[0.9989392,0.0001170569,0.0001603312,0.0005006175,0.0001283447,0.000001158803,5.297265e-7,0.00001990451,0.00013288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009333499,"threshold_uncertainty_score":0.5221254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057615963641059,"score_gpt":0.2112033836896629,"score_spread":0.2006272240532523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}