{"id":"W2167441016","doi":"10.1124/pr.58.4.11","title":"Direct G Protein Modulation of Cav2 Calcium Channels","year":2006,"lang":"en","type":"review","venue":"Pharmacological Reviews","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":249,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"N-type calcium channel; Voltage-dependent calcium channel; G protein-coupled receptor; G protein; Chemistry; Second messenger system; Cell biology; Neurotransmitter receptor; R-type calcium channel; Calcium; Calcium channel; Biophysics; P-type calcium channel; Neurotransmitter; Receptor; T-type calcium channel; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004525919,0.001278834,0.001351858,0.001211994,0.0002635982,0.0007364759,0.001266191,0.0008499188,0.003204677],"category_scores_gemma":[0.0004543727,0.0002837262,0.0003531345,0.001488063,0.000590863,0.00104038,0.0005993082,0.001470335,0.003121886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004956014,"about_ca_system_score_gemma":0.0005286862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005399197,"about_ca_topic_score_gemma":0.001208746,"domain_scores_codex":[0.9998738,0.00001455945,0.00001556897,0.00002887655,0.00005079445,0.00001643758],"domain_scores_gemma":[0.9998502,0.00006087609,0.00002251911,0.000008434106,0.00003710451,0.0000209097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001750816,0.00009384588,0.00009815295,0.008389257,0.00007977237,0.000310269,0.00004128236,0.0004644188,0.02090388,0.004486611,0.04015323,0.9248043],"study_design_scores_gemma":[0.0000705636,0.0001218053,0.0008823741,0.001065933,0.0001282296,0.001384151,0.00003891916,0.0001515054,0.005479754,0.003094284,0.9875565,0.00002595221],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003646477,0.9956512,0.0009058994,0.0003002336,0.0005878575,0.00001190135,0.00002869193,0.00003203066,0.002117603],"genre_scores_gemma":[0.001461916,0.9951662,0.000803503,0.0003020363,0.0004858132,0.00001623297,0.00006384618,0.000005417865,0.001695031],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003204677,"threshold_uncertainty_score":0.01072073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1298171064906035,"score_gpt":0.3977864360708988,"score_spread":0.2679693295802953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}