{"id":"W2167454178","doi":"10.1007/s12033-010-9286-1","title":"Enhanced Gene Delivery Mediated by Low Molecular Weight Chitosan/DNA Complexes: Effect of pH and Serum","year":2010,"lang":"en","type":"article","venue":"Molecular Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Canadian Institutes of Health Research","keywords":"Transfection; Lipofectamine; Chitosan; Gene delivery; Chemistry; Flow cytometry; Cytotoxicity; Dynamic light scattering; Biophysics; DNA; Fluorescence; Molecular biology; HEK 293 cells; Biochemistry; Gene; In vitro; Biology; Nanotechnology; Materials science; Recombinant DNA; Vector (molecular biology); Nanoparticle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001461479,0.0004002046,0.0004608477,0.0001742706,0.00006867814,0.00001821164,0.0005308939,0.001044424,0.00003102232],"category_scores_gemma":[0.0001502571,0.0003782776,0.0001647459,0.000220253,0.0005427201,0.000006385455,0.0003604977,0.0004039368,0.0000160654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006030667,"about_ca_system_score_gemma":0.00004764667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002496428,"about_ca_topic_score_gemma":0.00002270611,"domain_scores_codex":[0.9981057,0.0001105738,0.0003757894,0.0007448905,0.0001833964,0.000479665],"domain_scores_gemma":[0.9987724,0.00002177875,0.0001769764,0.0008327528,0.00007293677,0.0001231843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001295907,0.00006339765,0.0001995912,0.00004280809,0.0001719146,0.00003331253,0.000009801352,0.000003737885,0.9955827,0.00008164278,0.0002349582,0.003446536],"study_design_scores_gemma":[0.001125801,0.001247084,0.0002137015,0.00001965379,0.00005483396,0.00005188086,0.00001076937,0.00004962826,0.995501,0.00004874353,0.001301091,0.0003758121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932745,0.001842362,0.003550758,0.0003911513,0.000247923,0.00034739,0.0001229832,0.00006317077,0.0001597995],"genre_scores_gemma":[0.9981077,0.0005841643,0.000477677,0.0003531722,0.00003999901,0.00003904959,0.0003188022,0.0000527772,0.00002662496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004833271,"threshold_uncertainty_score":0.9998669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001774661095711281,"score_gpt":0.197743308054194,"score_spread":0.1959686469584827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}