{"id":"W2167507361","doi":"10.1002/cbic.200900343","title":"Molecular Basis for the Stereoselective Ammoniolysis of <i>N</i>‐Alkyl Aziridine‐2‐Carboxylates Catalyzed by <i>Candida antarctica</i> Lipase B","year":2009,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; University of Minnesota","keywords":"Substituent; Chemistry; Stereoselectivity; Aziridine; Stereochemistry; Enantiomer; Candida antarctica; Alkyl; Steric effects; Catalysis; Lipase; Organic chemistry; Enzyme; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002088153,0.0002513682,0.0002922681,0.00004048631,0.0001052204,0.00003057718,0.0003342127,0.0001673887,0.00001088795],"category_scores_gemma":[0.000234897,0.0001996394,0.0002956979,0.0003111449,0.000115103,0.000008723477,0.00005867299,0.00007902507,0.000001708694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002628493,"about_ca_system_score_gemma":0.00006326009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002554258,"about_ca_topic_score_gemma":0.000005714778,"domain_scores_codex":[0.9986892,0.0000297042,0.0003340837,0.0004776175,0.0001649585,0.0003044312],"domain_scores_gemma":[0.9987814,0.00006004438,0.0001945794,0.0006202316,0.0002594397,0.000084313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001490074,0.0001398776,0.0001364121,0.00002603305,0.0002030615,3.075508e-7,0.00006242982,0.00002807509,0.9920989,0.00003246335,0.005820552,0.001302851],"study_design_scores_gemma":[0.0006392024,0.0002565042,0.0001214429,0.00001599835,0.0002027891,0.000003506251,0.0001072554,0.0001344943,0.9939369,0.00004155994,0.004299472,0.0002408805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881322,0.005961683,0.004434902,0.0005307822,0.00005904954,0.0004506916,0.0001340462,0.00001645017,0.0002801421],"genre_scores_gemma":[0.9974417,0.0004408947,0.0002167132,0.0005525064,0.0001056488,0.0000818609,0.0009235182,0.00003051169,0.0002066431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009309449,"threshold_uncertainty_score":0.8141059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005065113020441581,"score_gpt":0.230028050507066,"score_spread":0.2249629374866244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}