{"id":"W2167507361","doi":"10.1002/cbic.200900343","title":"Molecular Basis for the Stereoselective Ammoniolysis of <i>N</i>‐Alkyl Aziridine‐2‐Carboxylates Catalyzed by <i>Candida antarctica</i> Lipase B","year":2009,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; University of Minnesota","keywords":"Substituent; Chemistry; Stereoselectivity; Aziridine; Stereochemistry; Enantiomer; Candida antarctica; Alkyl; Steric effects; Catalysis; Lipase; Organic chemistry; Enzyme; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001080777,0.0004849928,0.0002518691,0.0001156515,0.0002114496,0.0003485998,0.0005761248,0.0004251806,0.001190004],"category_scores_gemma":[0.0001538032,0.0002114611,0.0004048169,0.00008974102,0.0001943362,0.0001964752,0.0001916518,0.0004215952,0.0006187612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005812597,"about_ca_system_score_gemma":0.0004386067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002981139,"about_ca_topic_score_gemma":0.001652098,"domain_scores_codex":[0.9999501,0.000007548705,0.000003374,0.000009715328,0.0000166375,0.00001271355],"domain_scores_gemma":[0.9999517,0.00000750871,0.00001314428,0.000003850032,0.00001025249,0.00001351652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002061418,0.00005723772,0.0008548741,0.0001638238,0.00003448018,0.0004548523,0.00003017959,0.004005644,0.9860241,0.00438426,0.000252788,0.003531683],"study_design_scores_gemma":[0.0001040778,0.0003978953,0.004882916,0.00002712304,0.00005161998,0.0004504011,0.00006615292,0.04359479,0.9419827,0.001119343,0.007288281,0.00003459565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638644,0.001533941,0.02367084,0.0005117619,0.0001381934,0.0001423543,0.0005504796,0.00035889,0.009229111],"genre_scores_gemma":[0.9874061,0.0011511,0.008456784,0.00008614097,0.0000165421,0.00005160733,0.0006141494,0.00003178532,0.00218572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002981139,"threshold_uncertainty_score":0.005927563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005065113020441581,"score_gpt":0.230028050507066,"score_spread":0.2249629374866244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}